Section
A multicenter Chinese cohort of 509 initially treated MTC patients identifies new preoperative basal calcitonin thresholds (241.9, 693.9, 2378.5, 2787.1 pg/mL) that better predict central, ipsilateral lateral, bilateral/contralateral latera
A multinational team developed and valued the HNC-8D, an 8-dimension, head and neck cancer–specific health utility instrument derived from EORTC QLQ-C30/H&N43. Valuation in 250 participants yielded mean absolute prediction errors of 0.0
A VISION cohort analysis found myocardial injury after major head and neck surgery (MINS) in 11.9% overall and 23.8% of patients ≥75, strongly associated with 30‑day mortality and longer hospital stay; most events were clinically silent wit
A prospectively developed and validated algorithm (Expect-It) using clinical, exam, and transnasal videoendoscopy data improves sensitivity for selecting camera-assisted and awake tracheal intubation and increases first-attempt success in h
A multicenter Chinese cohort identifies new preoperative basal calcitonin thresholds (241.9, 693.9, 2378.5, 2787.1 pg/mL) that stratify risk of central, ipsilateral lateral, bilateral/contralateral lateral, and upper mediastinal lymph node
A multicenter cohort study shows adjuvant chemoradiotherapy improves disease-free and overall survival for oral cavity SCC patients with major extranodal extension (>2 mm) but provides no clear benefit for those with minor ENE (≤2 mm).
In a multi-center cohort of 345 surgically treated patients aged 70 or older with tonsil or base‑of‑tongue SCC, p16 positivity was associated with substantially better 5‑year overall and disease‑free survival compared with p16‑negative tumo
In a retrospective cohort of 158 HPV-positive tonsil SCC patients, omission of prophylactic contralateral tonsillectomy during TORS was not associated with worse survival and showed trends toward fewer hemorrhages, ED visits, and shorter ho
A multicenter propensity-matched cohort comparing adjuvant proton beam radiotherapy (PBRT) with intensity-modulated radiotherapy (IMRT) for olfactory neuroblastoma found no definitive differences in local control, recurrence-free survival,
A pooled analysis of two neoadjuvant nivolumab trials found that pathologic treatment effect >57% is associated with markedly improved 3‑year disease‑free and overall survival in HPV‑negative resectable HNSCC, suggesting pTE may be a use
An international multicenter cohort of 1,883 patients with radiologically growing vestibular schwannomas treated first‑line with radiotherapy showed a 10‑year tumor control rate of 76.1% (primary definition). Control estimates varied widely
The KATE trial (n=60) found no between-group difference in polysomnographic OAHI change after 3 years, though adenotonsillectomy improved disease-specific quality of life. Nearly 42% of watchful-waiting children later underwent surgery, sug
Early palliative care may reduce healthcare costs in head and neck cancer patients using tracheostomy or gastrostomy tubes but does not lessen aggressive hospital care or promote home deaths at the end of life.
This review synthesizes evidence on the timing of palliative care and the use of tracheostomy/gastrostomy tubes in head and neck cancer patients, highlighting their impact on end-of-life costs, quality, and care settings.
A multicenter randomized noninferiority trial found that GP observation after pediatric ventilation tube insertion produced audiometric outcomes at 2 years that were noninferior to routine ENT follow-up, with no increase in complications.
A multi-institutional propensity-matched cohort found no definitive differences in oncologic outcomes or grade ≥2 radiotherapy toxicities between adjuvant proton beam radiotherapy and IMRT for olfactory neuroblastoma, but estimates were imp
This critical synthesis of a 2020–2025 narrative review (327 DL studies) evaluates deep learning (DL) applications across diagnosis, prognosis, segmentation, and emerging intraoperative uses in otolaryngology and outlines practical steps fo
A Medicare claims analysis found that 15% of balloon sinus dilation (BSD) procedures lacked a CT within one year; 31.8% of otolaryngologists were outliers, with a small subset accounting for the majority of missed imaging—highlighting gaps
A Medicare claims study of 19,692 balloon sinus dilations found 15% lacked a CT within one year; 31.8% of otolaryngologists were outliers, with a small group accounting for most missed imaging, highlighting gaps in adherence to preoperative
An international cohort study developed and externally validated artificial neural networks that stratify older adults with locoregionally advanced head and neck squamous cell carcinoma (HNSCC) treated with definitive chemoradiation. Models
