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This article reviews real-world data supporting homologous recombination deficiency (HRD) testing in BRCA1/2 wild-type high-grade serous carcinoma and examines MYC amplification as a promising surrogate biomarker to guide PARP inhibitor the
This study evaluates the long-term incidence of liver cancer in chronic hepatitis B patients who clear hepatitis B surface antigen, finding significantly reduced cancer risk in younger patients without cirrhosis.
The Phase 2 TREASURE trial investigated the safety and efficacy of adding consolidative thoracic radiotherapy to atezolizumab maintenance in extensive-stage small cell lung cancer, revealing increased toxicity without survival benefit, unde
A multicenter cohort study demonstrates that circulating tumor DNA (ctDNA) is more accurate than Merkel cell polyomavirus (MCPyV) antibody testing in detecting recurrence of Merkel cell carcinoma, improving patient surveillance and risk str
This cohort study reveals differential melanoma survival outcomes linked to institutional settings and insurance types, highlighting the need for standardized care in advanced melanoma stages.
Pavurutamab demonstrates manageable safety and encouraging efficacy in heavily pretreated relapsed/refractory multiple myeloma, showing an overall response rate of 46.5% and median progression-free survival of 16.8 months at the recommended
This study identifies log odds of positive lymph nodes as the superior prognostic parameter in duodenal adenocarcinoma and introduces a validated nomogram that integrates this metric with clinical factors to improve individualized survival
A nationwide cohort study demonstrated that implementing a comprehensive multimodal prehabilitation program in colorectal cancer surgery patients lowers postoperative complications and shortens hospital stay across age and health status gro
This study evaluates the reading levels of gynecologic cancer educational materials from major cancer centers and nonprofits, revealing most exceed recommended standards, potentially limiting patient comprehension and informed decision-maki
A four-year post hoc analysis of the TOPAZ-1 trial confirms that durvalumab combined with gemcitabine and cisplatin offers a long-term survival benefit with manageable safety as first-line treatment for advanced biliary tract cancer.
The CASTL trial evaluated efficient combinations of tobacco cessation interventions for smokers undergoing lung cancer screening, identifying loss-framed messaging with nicotine replacement therapy as the most cost-effective strategy.
This article critically appraises a multicenter study validating the Anti-BNLF2b antibody (P85-Ab) assay, highlighting its superior sensitivity and specificity for early nasopharyngeal carcinoma detection compared to established EBV-based b
This review synthesizes evidence on AR-guided single-encounter localization for early-stage lung cancer, highlighting its noninferiority to CT-guided methods with benefits in patient comfort, radiation reduction, and procedural efficiency.
A comprehensive multicenter study reveals that ovarian immature teratomas with microscopic yolk sac tumor foci in pediatric patients have favorable outcomes, showing no increased recurrence risk despite higher tumor grade and stage.
An accessible, clinician-oriented summary of the 2026 Global Chordoma Consensus—multidisciplinary, anatomy-stratified recommendations on diagnosis, surgery, high‑dose conformal radiotherapy, follow-up, and supportive care for localized chor
This article explores how decreased TXNRD1 expression and specific TET2 mutations are linked to tagraxofusp resistance in BPDCN patients, highlighting biomarkers that could guide future therapeutic strategies.
A large retrospective study demonstrates that adding SGLT2 inhibitors to progestin therapy in women with benign uterine diseases reduces the risk of developing endometrial cancer and the need for hysterectomy.
This study reveals that dysregulated sphingolipid metabolism via SMPD1 supports KRAS-driven pancreatic cancer progression, identifying SMPD1 as a promising therapeutic target in pancreatic ductal adenocarcinoma.
Combining circulating methylated SEPT9 with alpha-fetoprotein significantly enhances early hepatocellular carcinoma detection in cirrhotic patients, outperforming AFP alone and allowing improved surveillance sensitivity and specificity.
A genetic study reveals that higher blood manganese levels are significantly associated with increased risks of oral cavity and HPV-positive oropharyngeal squamous cell carcinomas, suggesting a novel biomarker and potential target for preve
