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The phase 3 TORCH trial demonstrates that adding selective radiofrequency ablation after transarterial chemoembolization significantly improves progression-free and overall survival in patients with unresectable liver-confined hepatocellula
Oral nicotinamide reduces keratinocyte carcinoma incidence in high-risk individuals, providing significant cost savings and quality-adjusted life-year gains, supporting its role as a cost-effective preventive strategy.
A multi-institutional study of 483 patients shows that combining macroscopic (TBSr) and histologic (TRG) response to neoadjuvant therapy better stratifies recurrence risk after hepatectomy for colorectal liver metastases than either measure alone.
A meta-analysis of 23 observational studies shows higher MIND diet adherence is associated with a 55% lower cancer risk and reduced all-cause and CVD mortality. Separately, the MIND trial now provides genetic data to explore precision nutrition for cognitive decline.
The EORTC QLQ-VU34, a new disease-specific quality-of-life module for vulvar cancer patients, was developed and pre-tested across nine European countries, showing high relevance and applicability.
This study assesses the diagnostic benefits of concurrent EBUS-TBNA tissue sampling and liquid biopsy for next generation sequencing in NSCLC, highlighting complementary roles and implications for clinical practice.
This cohort study compares long-term survival and recurrence in esophageal adenocarcinoma patients achieving pathological complete response (pCR) after neoadjuvant FLOT chemotherapy versus CROSS chemoradiotherapy, highlighting better outcom
Venting gastrostomy tube placement in malignant bowel obstruction is linked to improved diet tolerance, fewer vomiting episodes, and reduced antiemetic use, with successful placement achievable in over 90% of cases despite challenges.
This post hoc analysis of the Neotorch phase 3 trial demonstrates that adding toripalimab to chemotherapy perioperatively in stage III resectable NSCLC improves tumor and nodal downstaging, reduces surgery cancellation, and significantly en
This study identifies key patient-level factors associated with failure to rescue after major gynecologic oncology surgery, emphasizing complication severity and physiological reserve over procedure complexity.
Hormone therapy initiated within one year after chemoradiotherapy in young patients with locally advanced cervical cancer is associated with reduced metabolic, skeletal, and cerebrovascular risks, and improved survival without increased onc
This study unravels how tumour-derived NGAL induces NETs that reprogram fibroblast subtypes via ITGA5, promoting immunosuppression and tumour progression in pancreatic ductal adenocarcinoma, suggesting combinatorial therapies to enhance imm
This study uncovers a novel DR5/Ligase 3 feedback mechanism that sustains immunogenicity and enhances immune checkpoint inhibitor response in mismatch repair-deficient colorectal cancer.
Medicare Advantage beneficiaries with cancer receive guideline-concordant treatment similarly to Traditional Medicare enrollees but at lower costs and comparable timeliness, highlighting implications for healthcare policy and cost-effective
This review highlights how EIF4A3-dependent nonsense-mediated mRNA decay selectively regulates the oncogenic AML1-ETO9a isoform in t(8;21) AML, influencing leukemic cell proliferation, chemosensitivity, and patient survival through an isofo
This article examines the clinical and psychosocial factors influencing BRCA previvors’ decisions on timing delayed oophorectomy after risk-reducing salpingectomy, highlighting the nuanced balance between cancer anxiety and menopausal
This article reviews the development and preclinical evaluation of C9-66 CAR-T cell therapy targeting oncofetal chondroitin sulfate in pancreatic cancer, highlighting metabolic and microenvironmental optimizations that improve efficacy and
SOX9 is a pivotal regulator of SPEM cell plasticity driving gastric metaplasia and carcinogenesis. Therapeutically targeting SOX9 may prevent the progression of pre-cancerous lesions to gastric cancer by blocking metaplastic evolution.
Dual resistance to asparaginase and PD-1 inhibitors in extranodal NK/T-cell lymphoma leads to poor prognosis; chidamide-containing regimens show promising survival benefits in this difficult-to-treat population.
The BrIMA trial demonstrates that specimen PET-CT imaging significantly improves intraoperative detection of positive margins during breast-conserving surgery for early-stage breast cancer, reducing re-excision rates and enhancing surgical
