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This article explores how the deubiquitinase JOSD1 drives HCC progression by modulating a novel PTM switch on PGAM1, promoting glycolysis and immune evasion while providing a new target for combined immunotherapy.
A large South Korean cohort found ATA-guideline de-escalation reduced total thyroidectomy, RAI use, and permanent hypocalcemia in papillary thyroid carcinoma, without significant loss of 5-year disease-free survival.
Introduction and Context Despite being highly preventable, cervical cancer remains a significant health threat. The…
Single-cell analysis reveals CD276/B7-H3 as a critical regulator of chemoresistance in pancreatic ductal adenocarcinoma, highlighting its dual role in promoting basal-like tumor states and immune evasion.
This cohort study highlights the underutilization of timely palliative care in adolescent and young adult cancer patients opting for MAID, with significant symptom burden and complex psychosocial factors influencing end-of-life decisions.
Baseline ctDNA levels predict early progression and poor survival in untreated follicular lymphoma, outperforming traditional risk scores like FLIPI. This study highlights ctDNA’s potential as a stratification tool in clinical trials.
A large claims-based study reveals pembrolizumab dominates immunotherapy prescribing for head and neck cancer, with minimal usage growth since FDA approval. Immune-related adverse events occurred in 41.2% of patients, linked to specific com
Radiation-induced otitis media with effusion (RI-OME) shows heightened bacterial colonization with opportunistic pathogens. Although microbial presence predicts early recurrence (≤4 weeks post-tympanocentesis), it does not independently inf
A culturally tailored educational intervention significantly improved clinical trial knowledge and self-efficacy among African American and Hispanic women, highlighting the potential of community partnerships to address disparities in gynec
The American College of Obstetricians and Gynecologists (ACOG) has qualifiedly endorsed the 2026 WPSI cervical cancer screening guidelines. This article details the core recommendations, highlights key updates including self-collection opti
A novel machine-learning model incorporating clinical, ultrasonographic, and molecular features predicts occult central lymph node metastasis in papillary thyroid cancer, with RET fusion positivity identified as a key risk factor.
A retrospective study reveals robotic gastrectomy achieves higher textbook outcome rates than laparoscopic and open surgery, correlating with improved 1-year survival in gastric cancer patients.
A new study reveals that selective molecular profiling with MMR/p53 IHC followed by NGS for p53-abnormal tumors is more cost-efficient than universal NGS for advanced endometrial cancer, reducing unnecessary testing by 57%.
The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.
Elevated levels of inflammatory and cardiac biomarkers are linked to higher risks of venous thromboembolism and bleeding in cancer patients, according to a post hoc analysis of the AVERT trial.
A cohort study of over 1 million cancer patients revealed significant reductions in 1-year survival rates during 2020-2021 compared to pre-pandemic trends, with an estimated 17,390 excess cancer deaths attributable to pandemic-related care
PRMT5 inhibition sensitizes B-cell lymphomas to ferroptosis by disrupting the PRMT5-ATF5-SLC7A11 axis, offering a novel therapeutic strategy for relapsed or refractory disease.
An updated meta-analysis suggests lymph node dissection in intrahepatic cholangiocarcinoma may improve survival when it is truly adequate, especially when at least six nodes are retrieved and confounding is reduced.
In a prospective cohort of 172 vulvar surgery patients, prophylactic antibiotics were not associated with fewer postoperative infections or complications, supporting the need for a randomized trial.
A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.
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