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A comprehensive meta-analysis suggests that for intermediate-risk papillary thyroid carcinoma with unilateral lateral lymph node metastasis, lobectomy provides oncological outcomes comparable to total thyroidectomy, challenging the necessit
A large-scale SEER database study reveals that total thyroidectomy significantly improves disease-specific survival for patients with cN1b papillary thyroid cancer. However, this survival advantage is attenuated in younger populations, pote
A systematic review and meta-analysis of 26 RCTs reveals that prophylactic tranexamic acid (TXA) significantly reduces blood loss and transfusion needs in general surgery. While safety profiles are favorable, procedural nuances—particularly
A randomized clinical trial demonstrates that adding low-dose intrathecal morphine to transversus abdominis plane block significantly improves 24-hour recovery quality and reduces opioid consumption in laparoscopic colorectal surgery patien
A multi-center study in JAMA Surgery introduces a validated 13-point risk score to identify recurrence risk in LN-negative PanNET patients, revealing that tumor size, grade, and lymphovascular invasion are critical prognostic drivers even w
The CARE feasibility trial demonstrates that a preoperative low-energy total diet replacement program is safe and effective for colorectal cancer patients with excess weight. Significant weight loss was achieved without compromising lean mu
A randomized clinical trial demonstrates that combining gastric electrical stimulation with pyloroplasty significantly outperforms pyloroplasty alone, providing superior symptom relief and reducing hospitalizations for patients with medicat
Randomised trials show breast surgery improves local disease control but not overall survival in de novo metastatic breast cancer.
This review synthesizes evidence demonstrating that 4-factor prothrombin complex concentrate (4F-PCC) offers superior hemostatic efficacy and safety compared to frozen plasma in managing coagulopathic bleeding during cardiac surgery, suppor
The CLIP-II trial evaluated dimethyl sulfoxide-cryopreserved platelets with extended shelf-life against conventional liquid-stored platelets in cardiac surgery bleeding, finding noninferiority was not established and cryopreserved platelets
A pragmatic multicenter randomized trial found that coach-supported, home-based multimodal prehabilitation before elective noncardiac surgery did not reduce 30-day postoperative disability or in-hospital complications in older adults with f
An international randomized trial found minimally invasive pancreatoduodenectomy (mostly robotic) noninferior to open surgery for 90‑day overall complications and modestly faster functional recovery, with lower fistula and wound‑infection r
A validated NCDB-derived risk score using age, sex, race, comorbidity, stage, neoadjuvant therapy, length of stay and conversion identifies patients at markedly different 30-day mortality risk after proctectomy (0.8%–4.5%).
This multicenter study defines international perioperative reference values for total pancreatectomy (TP). Even low‑risk TP carries higher morbidity and mortality than pancreatoduodenectomy; outcomes worsen with vascular resection or conver
A Medicare claims study of 19,692 balloon sinus dilations found 15% lacked a CT within one year; 31.8% of otolaryngologists were outliers, with a small group accounting for most missed imaging, highlighting gaps in adherence to preoperative
A randomized trial found personalized, remotely coached prehabilitation improved preoperative physical and cognitive function, produced distinct immunologic dampening of inflammatory signaling, and reduced moderate-to-severe postoperative c
A large multicenter cohort shows that both diagnosed and previously unrecognized diabetes (by HbA1c) are common in general surgery patients and independently linked to higher 30‑day complications, readmissions, and mortality—supporting rout
The UMC‑UPPERGI‑01 randomized trial (n=208) found laparoscopic distal gastrectomy with D2 lymphadenectomy had similar 30‑day morbidity and mortality to open surgery for clinical T4a gastric cancer, despite longer operative times and modestl
Interim results from the phase 2 PHERFLOT trial show a 48.4% pathological complete response and a 67.7% major pathologic response after four cycles of pembrolizumab, trastuzumab and FLOT in localized HER2‑positive esophagogastric adenocarci
In high–cardiac-risk veterans after major vascular or general surgery, a liberal postoperative transfusion threshold (Hb <10 g/dL) did not reduce 90‑day death or major ischemic events compared with a restrictive threshold (Hb <7 g/dL)
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