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This systematic review and meta-analysis evaluates the efficacy and safety of pharmacological therapies for functional constipation in children, identifying polyethylene glycol as the preferred first-line treatment based on moderate-certain
This meta-analysis reveals that MetALD confers higher risks of liver-related events, hepatocellular carcinoma, and extrahepatic cancers compared to MASLD, while mortality and cardiovascular risks are similar, emphasizing tailored clinical a
This study investigates whether sterile lyophilised fecal filtrate is as effective as traditional donor stool in preventing recurrent C. difficile infection, highlighting the importance of live microbes in treatment efficacy.
The ZSAB-TransGOLP study demonstrates the promising efficacy and manageable safety of combining tislelizumab, lenvatinib, and GEMOX chemotherapy as a conversion therapy for unresectable locally advanced biliary tract cancer, achieving a 63%
This Cochrane review update evaluates duct-to-mucosa pancreaticojejunostomy compared to other anastomotic techniques following pancreaticoduodenectomy for preventing postoperative pancreatic fistula, finding very low-certainty evidence and
Four RCTs comparing robotic and laparoscopic Nissen fundoplication for GERD show equivalent patient outcomes but longer operative times and higher costs with robotics, questioning its routine use.
An umbrella review synthesizes evidence from 156 RCTs assessing probiotics’ effects on cognitive-related outcomes, showing moderate- to high-quality support for cognitive benefits but highlighting need for further trials on strains an
This systematic review and meta-analysis of randomized controlled trials finds no significant association between proton pump inhibitor use and increased risk of Clostridioides difficile infection, challenging earlier observational data and
Combining MRI and CT improves detection of nonviable disappearing colorectal liver metastases but does not reliably confirm nonviability, challenging the management of such lesions post-chemotherapy.
This review synthesizes evidence comparing postoperative pulmonary complications (PPCs) between robot-assisted surgery (RAS) and conventional laparoscopic surgery (CLS) in abdominal procedures, highlighting the pivotal role of ventilation d
A 6-week multimodal prehabilitation program combining exercise and nutrition significantly reduces postoperative morbidity in sarcopenic patients undergoing major liver resection, highlighting a promising strategy to improve surgical outcom
Metabolic dysfunction and MASLD elevate hepatocellular carcinoma risk in chronic hepatitis B patients. The PAGE-B score effectively stratifies this risk, especially in non-cirrhotic patients, while cirrhotic patients still require careful m
The EASI trial compared a once-daily 1600 mg 5-ASA tablet with the conventional three 800 mg tablet regimen for ulcerative colitis, finding similar adherence and relapse rates, suggesting a feasible simpler alternative.
The IL23R1142G>A genetic variant strongly predicts paradoxical psoriasis in inflammatory bowel disease patients undergoing anti-TNFα therapy, guiding personalized treatment decisions.
This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies
In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved
Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.
This study demonstrates that empirical donor exclusion combined with a two-dose capsule regimen significantly improves cure rates in Clostridioides difficile infection treated with encapsulated faecal microbiota transplantation (FMT).
One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.
A phase 2b trial demonstrates that several noninvasive tests reliably reflect treatment response to semaglutide in patients with metabolic dysfunction-associated steatohepatitis, correlating with histologic improvements over 72 weeks.
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