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This study uncovers a novel DR5/Ligase 3 feedback mechanism that sustains immunogenicity and enhances immune checkpoint inhibitor response in mismatch repair-deficient colorectal cancer.
Emergency departments serve as vital venues for hepatitis C virus screening, particularly for persons experiencing homelessness who exhibit higher HCV prevalence and face healthcare access barriers. Evidence supports nontargeted screening i
This article explores recent outbreaks of Cyclospora and Cryptosporidium infections in the U.S., their transmission, clinical features, diagnosis, treatment, and prevention, highlighting the public health impact and clinical challenges.
Older adults with MASLD, especially those aged 75 and above, experience a high burden of polypharmacy linked to multimorbidity, necessitating careful medication management to balance disease control and geriatric vulnerabilities.
Delaying additional surgery beyond 35 days after noncurative endoscopic submucosal dissection (ESD) in early gastric cancer reduces operative time and blood loss, potentially improving perioperative outcomes.
Robotic cholecystectomy for complex gallbladder disease reduces postoperative complications and interventions compared to laparoscopic surgery without increasing total costs, suggesting a strategic role for robotic platforms in complex case
The G-MASLD study evaluated the diagnostic accuracy of non-invasive fibrosis tests across 41 countries, revealing regional variability and identifying Agile-3+ and Agile-4 as the most accurate for advanced fibrosis and cirrhosis in MASLD pa
SOX9 is a pivotal regulator of SPEM cell plasticity driving gastric metaplasia and carcinogenesis. Therapeutically targeting SOX9 may prevent the progression of pre-cancerous lesions to gastric cancer by blocking metaplastic evolution.
This multicenter retrospective study examines colorectal dysplasia and malignancy outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease undergoing liver transplantation and colectomy, revealing comparable 5
The ENDO trial demonstrates that the EndoBarrier duodenal-jejunal bypass liner significantly improves glycemic control and induces meaningful weight loss in patients with poorly controlled type 2 diabetes and obesity, with an acceptable saf
A multicenter study reclassifies pediatric NAFLD under the steatotic liver disease framework, revealing most children meet MASLD criteria, while highlighting alcohol and medication-related reclassifications that inform diagnosis and managem
This study evaluates the long-term incidence of liver cancer in chronic hepatitis B patients who clear hepatitis B surface antigen, finding significantly reduced cancer risk in younger patients without cirrhosis.
This study reveals that bisphenol F exposure aggravates cardiomyopathy under hemodynamic stress through gut microbiota metabolism, highlighting a novel gut-heart axis involving N-acetylputrescine and potential therapeutic targets.
This study identifies log odds of positive lymph nodes as the superior prognostic parameter in duodenal adenocarcinoma and introduces a validated nomogram that integrates this metric with clinical factors to improve individualized survival
Serum bile acid levels measured within the first year after Kasai procedure accurately predict portal hypertension and high-risk esophageal varices development within five years in biliary atresia patients, offering a valuable non-invasive
A genome-wide meta-analysis of 2.8 million individuals reveals genetic links between irritable bowel syndrome, brain-gut pathways, and cardiometabolic traits, highlighting novel therapeutic targets involving triglyceride metabolism.
The REScUE study compared two ustekinumab dosing intensification regimens after secondary loss of response in Crohn’s disease, finding no superiority of more frequent dosing regarding steroid-free remission at 48 weeks.
A four-year post hoc analysis of the TOPAZ-1 trial confirms that durvalumab combined with gemcitabine and cisplatin offers a long-term survival benefit with manageable safety as first-line treatment for advanced biliary tract cancer.
Young patients undergoing resection for intraductal papillary mucinous neoplasms (IPMNs) exhibit excellent long-term quality of life comparable to the general population despite endocrine and exocrine insufficiencies.
This study evaluates the added value of endoscopic ultrasound (EUS) and fine needle aspiration (FNA) after MRI in assessing pancreatic cystic neoplasms, demonstrating significant improvement in diagnostic specificity and clinical decision-m
