Highlights
This population-based study of 176,780 adults in Stockholm reveals concerning trends in primary hyperparathyroidism epidemiology. Between 2009 and 2020, age- and sex-adjusted incidence rose from 2.81 to 4.28 per 10,000 person-years, representing a 52% increase. Prevalence surged dramatically from 0.35 to 4.76 per 1,000 individuals. Alarmingly, only 52% of biochemically confirmed cases received clinical diagnosis, while surgical treatment remained stable at 4-5% annually after 2013. Women aged 70 years and older exhibited the steepest increase in incidence, suggesting demographic shifts are driving this epidemic.
