Our website uses essential cookies and, with your consent, additional cookies to measure performance and improve our services. Cookie Policy.
You can change your choice at any time.
A randomized, double‑blind crossover trial in healthy volunteers found lacosamide acutely reduced strength–duration time constant and other excitability metrics in large myelinated peripheral fibers; pregabalin and tapentadol produced no co
A single‑center RCT found that starting a titrated norepinephrine infusion at anesthesia induction reduced intraoperative hypotension and lowered 30‑day medico‑surgical complications compared with reactive ephedrine boluses in high‑risk abd
In mechanically ventilated patients with early acute hypoxemic respiratory failure, continuous IV sedation produces EEG patterns (EEG Ups) not seen in natural sleep; these patterns correlate with sedation dose, drug combinations, clinical s
A population PK–PD study in healthy volunteers found that a physiologic model incorporating CO2 kinetics and a ventilatory controller estimates fentanyl potency for ventilatory depression at ~2.3 ng/mL—substantially lower than estimates fro
A randomized trial found that maintaining high intraoperative urine output (≥3 ml·kg−1·h−1 or ≥200 ml·h−1) during cytoreductive surgery and cisplatin‑based HIPEC reduced 7‑day postoperative AKI from 39.3% to 21.4% and lowered major 30‑day c
In a mouse spared nerve injury model, pregabalin—but not morphine—restored REM sleep, normalized locomotor and temperature circadian rhythms, and reversed spinal circadian gene changes. Findings suggest analgesic choice can differentially a
A Cochrane update (2025) of 69 randomized trials found restrictive RBC transfusion thresholds (typically Hb 7–8 g/dL) cut transfusion exposure ~42% without increasing 30‑day mortality overall, but liberal strategies improved long‑term neuro
The ReCePI randomized phase 3 trial found that amustaline/glutathione pathogen-reduced red blood cells produced similar rates of acute kidney injury compared with conventional transfusion after cardiac or thoracic-aorta surgery, with few tr
A prospective pediatric study shows forehead NIRS (INVOS 5100C) underestimates regional oxygenation in children with darker skin, producing clinically meaningful bias and raising concerns about equity in monitoring and device validation.
An international study reveals that postoperative vasopressor infusions after noncardiac surgery vary widely across hospitals and are linked to higher mortality and complications, highlighting the need for optimized management strategies.
This network meta-analysis of 49 RCTs demonstrates that digital health interventions, notably virtual reality, 2D videos, and 2D games, significantly reduce perioperative anxiety and pain and improve induction compliance in pediatric surgic
A customized protective palatal obturator significantly reduces oral tissue injury during intubation in newborns undergoing cleft lip surgery, improving safety without prolonging intubation.
The PRETREAT trial found that proactive blood pressure management tailored by risk of intraoperative hypotension does not reduce postoperative functional disability compared to standard care in noncardiac surgery.
The IMPROVE-multi randomized clinical trial found that tailoring perioperative blood pressure targets to individual preoperative nighttime MAP levels did not reduce postoperative organ injury or mortality compared to routine management in h
This article reviews a large retrospective study evaluating acute normovolemic hemodilution (ANH) in adult cardiac surgery, demonstrating its association with reduced blood transfusions and cost savings, yet highlighting its underuse in cli
This trial found that adjunctive dexmedetomidine did not reduce opioid use, pain scores, or pulmonary complications in nonintubated ICU patients with traumatic rib fractures, challenging its routine analgesic use in this setting.
The FiiRST-2 trial found no superiority of clotting factor concentrates over frozen plasma for initial resuscitation in severely bleeding trauma patients, with similar transfusion needs and safety outcomes.
The BP-CARES randomized trial found no cardiovascular benefit of intensive intraoperative blood pressure management (MAP ≥80 mm Hg) over conventional targets in high-risk major abdominal surgery patients.
Co-administering midazolam with dexmedetomidine in elderly NSCLC patients undergoing lobectomy enhances hemodynamic stability and reduces perioperative stress response, potentially improving recovery outcomes without increasing adverse even
This randomized trial demonstrates that single-shot intercostal nerve block offers noninferior pain relief compared to thoracic epidural analgesia after thoracoscopic lung resection, with benefits in opioid reduction, mobility, and shorter
Open language-specific specialty feeds and department pages.