Section
A large RCT found that adding behavioral therapies to patient-centered opioid tapering did not improve taper success at 12 months, though CBT may reduce adverse effects; complementary digital support programs show feasibility but require fu
A novel 3D-printed transoral airway device, the Orocannula, provides reliable oxygen delivery and CO2 monitoring during sedation with high retention and minimal flow obstruction, potentially improving patient safety during procedural sedati
In hypertensive high-risk patients undergoing major abdominal surgery, targeting an intraoperative mean arterial pressure ≥80 mmHg reduces postoperative organ dysfunction and acute kidney injury compared to the standard target of ≥65 mmHg.
This study reveals that general anesthesia selectively modulates ketamine-induced EEG changes, preserving beta-gamma oscillations while attenuating theta augmentation, highlighting discrete neurophysiologic components underlying ketamine
In PSV patients, passive leg raising–induced PPV change predicted preload responsiveness, especially when inspiratory effort was low by P0.1.
This review analyzes significant inter-hospital variations in opioid prescribing for vaginal births with complications, highlighting the need for standardized postdischarge pain management protocols to reduce unnecessary opioid exposure.
The American Thyroid Association’s updated consensus refines who can safely undergo outpatient thyroid surgery and what teams must do before, during, and after the operation to reduce complications.
A rare, severe neurologic complication has been linked to general anesthesia in patients of maternal Venezuelan descent. Ophthalmologists should screen for ancestry and family history, involve anesthesiology early, and consider genetic eval
A national study reveals significant state-level and urban-rural variations in opioid prescribing following toothache diagnoses, with 15 states exceeding the national average and rural areas showing slightly lower prescription rates.
The Risk Analysis Index (RAI) significantly outperforms the modified frailty index-5 (mFI-5) in predicting mortality and major complications after uvulopalatopharyngoplasty, supporting its adoption for preoperative risk assessment in sleep
The SHOSREB trial demonstrates that remimazolam besylate is non-inferior to propofol for short-term light sedation in mechanically ventilated ICU patients, with both agents achieving 97.5% successful sedation rates and comparable time withi
Researchers using human stem cell models have discovered that macrophages actively amplify the electrical signals of damaged nerves, driving the spontaneous pain characteristic of neuropathy, offering a new target for non-opioid pain relief
A randomized clinical trial demonstrates that wearable Transcutaneous Electrical Acupoint Stimulation (TEAS) provides superior 2-hour remission and significantly lower 24-hour relapse rates compared to intravenous metoclopramide for moderat
A groundbreaking human iPSC-derived co-culture study reveals that macrophages respond to neuronal injury by adopting a pro-algesic state, directly intensifying spontaneous neuronal firing—a key driver of chronic neuropathic pain and a novel
A large prospective cohort study reveals that epidural anesthesia significantly increases the success rate of external cephalic version (70.0%) and subsequent vaginal delivery (72.2%) compared to intravenous remifentanil, despite a higher i
A randomized clinical trial demonstrates that while CYP2D6 genotyping significantly shifts opioid prescribing patterns for poor and intermediate metabolizers, it does not improve pain control or reduce opioid consumption within the context
This cohort study demonstrates that postoperative sleep architecture is differentially disrupted based on surgical risk. High-risk procedures cause prolonged deficits in REM and deep sleep, which are associated with increased complications,
A randomized clinical trial demonstrates that wearable transcutaneous electrical acupoint stimulation (TEAS) provides superior symptom relief and significantly lower relapse rates compared to intravenous metoclopramide in managing moderate
This systematic review and network meta-analysis of 52 randomized trials evaluates pharmacological agents for controlled hypotension in ESS, identifying diltiazem, esmolol, and dexmedetomidine as the most effective for reducing intraoperati
A randomized, double-blind trial confirms that preemptive magnesium sulfate reduces intraoperative hemodynamic instability by nearly 50% in patients undergoing pheochromocytoma and paraganglioma resection, providing a safe and effective adj
