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This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.
This study evaluates ECMO as a standalone respiratory support in ARDS patients avoiding invasive mechanical ventilation, highlighting outcomes, strategy failures, and mortality implications.
This study evaluates respiratory support and mortality trends in Andes virus-induced hantavirus cardiopulmonary syndrome (HCPS) across Chile, highlighting increased mortality during the COVID-19 pandemic period and a high requirement for in
This study explores rehabilitation initiation, progression, and physical activity levels in adult ECMO patients, highlighting early active rehabilitation feasibility and varied activity trajectories based on clinical goals.
This bibliometric study reveals persistent gender disparities in authorship of critical care publications, with women better represented in low- and middle-income countries and a modest increase in female authorship from 2018 to 2022 global
This article explores hyperinflammatory and hypoinflammatory phenotypes in severe pneumonia, their clinical impact, and translational mouse models that inform precision therapeutic strategies.
This study evaluates how ICU room characteristics, including room type and visibility, influence mortality and length of stay, finding single rooms increase length of stay without affecting mortality.
The SAVE-O2 AI trial demonstrates autonomous oxygen titration significantly improves normoxemia maintenance and reduces hypoxemia duration compared to manual methods in hospitalized acutely ill adults.
This study emulated a target trial to compare ultra-early (0-3h) versus early (>3-6h) vasopressin initiation after norepinephrine escalation in septic shock, revealing significant mortality and renal therapy benefits with ultra-early use
This study highlights varied outcomes of renal replacement therapy in critically ill patients, identifying subgroups who may benefit despite an overall increase in mortality risk.
High-dose rocuronium (>1.2 mg/kg) is associated with improved first-attempt intubation success in ICU patients, though this benefit was not observed in the ED setting. Further randomized trials are needed to confirm these findings.
A multicenter study investigated whether initiating a 1-hour resuscitation bundle—including antibiotics, fluids, vasopressors, and hydrocortisone—in the prehospital setting influences 28-day mortality in septic shock, finding no significant
Secondary analysis of two multicenter trials reveals that high-dose rocuronium (>1.2 mg/kg) improves first-attempt intubation success in ICU patients but not in the emergency department, highlighting a potential dose-dependent effect on
This review synthesizes evidence on the adoption and billing practices of telemedicine critical care for Medicare beneficiaries from 2018 to 2024, highlighting pandemic-driven shifts, provider and hospital characteristics influencing utiliz
The APS Consortium establishes a large, prospective cohort of critically ill adults with ARDS, pneumonia, and sepsis to enable biologically based phenotyping, leveraging rich clinical data and biospecimens for improved understanding and the
A large Indian ICU registry study reveals no significant difference in mortality between sexes despite females receiving less invasive organ support in critical care.
A randomized trial showed no significant differences in 6- and 12-month cognitive, physical, and quality of life outcomes between early restrictive and liberal fluid resuscitation in sepsis-induced hypotension.
AI-enabled point-of-care EEG monitoring accurately measures seizure burden, showing a dose-dependent association with unfavorable clinical outcomes at discharge, highlighting its potential in critical care.
This study explores how delays in transferring patients from the emergency department to the ICU influence hospital mortality, revealing diagnosis- and hospital-type-specific associations, particularly in cardiac arrest and trauma cases.
In a multicenter phase 2 trial, early intravenous vitamin C did not improve post-cardiac arrest organ dysfunction and the 10 g dose was associated with worse outcomes, including renal, cardiac, and neurologic signals.
