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A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.
MICROINHALO found that automatic cuff pressure control plus subglottic secretion drainage did not reduce tracheal colonization, but it was linked to fewer ventilator-associated pneumonia cases in critically ill intubated patients.
In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.
A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.
In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were
A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.
A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.
A structured exercise program combining mobility therapy and resistance training in ECMO patients proved feasible and safe, with longer session times correlating with better functional performance.
Early low-calorie and low-protein nutrition in critically ill patients with shock does not worsen renal outcomes compared to standard feeding, per NUTRIREA-3 post hoc analysis.
A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l
The SHOSREB trial demonstrates that remimazolam besylate is non-inferior to propofol for short-term light sedation in mechanically ventilated ICU patients, with both agents achieving 97.5% successful sedation rates and comparable time withi
Bayesian re-analysis of the RELAx trial suggests a 75-78% probability that a lower PEEP strategy is superior to higher PEEP in ICU patients without ARDS, with even higher benefits observed in specific clinical subgroups.
Recent multicenter data indicates that red blood cell exchange transfusion (ET) provides a nearly five-fold reduction in mortality and readmission for patients with severe babesiosis, challenging earlier smaller-scale observations.
A prospective study highlights significant discrepancies between point-of-care and central laboratory sodium and potassium measurements in the ICU, revealing a 10.48 mmol/L limit of agreement for sodium and a widespread lack of physician aw
Expert consensus highlights a shift in shock treatment, emphasizing that standardized protocols must give way to personalized, physiology-driven bedside care to prevent iatrogenic injury and improve survival.
This review analyzes the analytical biases between direct and indirect potentiometry for sodium and potassium measurement in critical care, highlighting significant clinical classification discrepancies and a widespread lack of physician aw
A prospective cohort study demonstrates that antipsychotic use in critically ill patients is significantly associated with fewer catatonia-free days, suggesting that dopamine blockade may be a primary driver of catatonic syndromes in intens
A large-scale trial in Brazilian ICUs found that daily chlorhexidine bathing did not lower overall nosocomial infection rates but significantly reduced multi-drug resistant pathogen isolation and the use of high-priority reserve antibiotics
The ARISS randomized clinical trial found that 20% albumin supplementation to maintain serum levels ≥3.0 g/dL is safe in septic shock but does not significantly improve 90-day survival compared to standard crystalloids, though the studyR
The PreVent 2 trial demonstrates that specialized endotracheal tubes with subglottic suction and polyurethane cuffs do not significantly reduce ventilator-associated complications or improve 6-month laryngeal, cognitive, or quality-of-life
