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A large systematic review identified prior knee injury, older age, and high bone mineral density as predictors of incident radiographic knee osteoarthritis; overweight/obesity and prior injury explained ~14% of cases—highlighting prevention
In a 9-year OAI cohort analysis, baseline self-reported moderate physical activity was linked to lower knee replacement risk in KL grade 2 but to higher risk in KL >2; high activity showed no clear effect. Results support severity-tailor
In a longitudinal analysis of 4,316 Osteoarthritis Initiative participants, baseline sarcopenia screened by SARC-F and chair-stand testing was associated with accelerated radiographic and symptomatic knee OA progression over 24–48 months an
Two large longitudinal cohorts show baseline chondrocalcinosis is associated with ~75% higher odds of developing radiographic knee osteoarthritis over long-term follow-up, suggesting calcium crystal deposition may be a contributing factor i
A large South Korean cohort study suggests that sodium-glucose cotransporter-2 (SGLT-2) inhibitors reduce the incidence of autoimmune rheumatic diseases by 11% compared to sulfonylureas in adults with type 2 diabetes, indicating potential i
This RCT shows dapagliflozin does not significantly affect bone metabolism or mineral density in lupus nephritis patients over 12 months, alleviating concerns about SGLT2 inhibitors’ bone safety in this population.
This phase 2 trial demonstrates that bexotegrast, a dual αvβ6/αvβ1 integrin inhibitor, significantly reduces active type I collagen deposition in IPF lungs, indicating antifibrotic potential and favorable lung remodeling over 12 weeks.
This article reviews a pivotal phase 3 trial demonstrating telitacicept’s efficacy and safety in active SLE, highlighting its potential as a novel targeted therapy.
The FDA has approved Roche’s obinutuzumab for active lupus nephritis in adults, offering a twice-yearly dosing regimen that achieved nearly 50% complete renal remission in trials, marking a significant advancement in lupus nephritis managem
This post hoc analysis of the ADVOCATE trial demonstrates that avacopan is effective and safe for treating ANCA-associated vasculitis in patients aged 65 and older, achieving sustained remission with reduced glucocorticoid exposure and toxi
Avacopan, a complement C5a receptor inhibitor, shows comparable remission rates to prednisone taper in ANCA-associated vasculitis patients receiving cyclophosphamide, with benefits of lower relapse, improved kidney function, and reduced glu
A comprehensive review of a Japanese cohort study assessing rituximab and cyclophosphamide efficacy in severe microscopic polyangiitis and GPA, highlighting clinical implications.
This article examines the prevalence, risk factors, and diagnostic screening strategies for rheumatoid arthritis-associated interstitial lung disease (RA-ILD) in early rheumatoid arthritis, highlighting age and disease activity as key predi
A retrospective study of 88 patients with genetically confirmed VEXAS syndrome reveals that azacitidine improves inflammatory symptoms, cytopenias, and reduces UBA1 mutant clone burden with an acceptable safety profile, supporting its use a
This study characterizes UBA1 mutation effects in VEXAS syndrome and identifies UBA6 as a compensatory enzyme and promising therapeutic target, highlighting selective inhibition to combat mutant hematopoietic clones.
This study reveals that VEXAS syndrome-associated anemia results from a mosaic erythroblastopenia due to selective UBA1 mutations in early erythroid precursors, advancing understanding of its pathophysiology and therapeutic implications.
A systematic review and meta-analysis of RCTs indicates Pilates may improve pain and function in knee osteoarthritis patients, though evidence quality is low and safety data insufficient. Caution is warranted in interpreting results, highli
In a large phase 3 trial, simvastatin 80 mg daily did not reduce disability progression in secondary progressive multiple sclerosis, challenging prior phase 2 results and underscoring the complexity of neurodegeneration in SPMS.
Methotrexate-induced osteopathy, predominantly affecting postmenopausal women with rheumatoid or psoriatic arthritis, presents as stress fractures in the lower limbs. Early MRI or bone scintigraphy aids diagnosis, and discontinuing methotre
The 2025 Nobel Prize honors the groundbreaking discovery of regulatory T cells (Tregs), key immune modulators that maintain tolerance and prevent autoimmunity, inspiring new therapies for autoimmune disease, transplantation, and cancer.
