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A multicenter randomized trial shows diacerein provides no clinical benefit over placebo for knee pain in patients with MRI-confirmed inflammation, despite its theoretical role as an IL-1β blocker.
A randomized clinical trial demonstrates that while CYP2D6 genotyping significantly shifts opioid prescribing patterns for poor and intermediate metabolizers, it does not improve pain control or reduce opioid consumption within the context
The PROP OA trial demonstrates that adding compartment-specific knee bracing and adherence support to standard exercise and advice significantly improves pain and function in patients with knee osteoarthritis, offering a safe and effective
The SCIENCE multicentre randomized trial demonstrates that surgical fixation for displaced medial epicondyle fractures in children provides no functional advantage over non-surgical care, carries higher complication risks, and is not a cost
A 5-year randomized controlled trial reveals that combining ACL reconstruction with anterolateral ligament (ALL) reconstruction using hamstring autograft significantly outperforms bone-patellar tendon-bone autograft alone, reducing graft fa
Brazilian scientists have developed Polylaminin, a protein derived from human placenta that stimulates nerve regeneration. In early trials, six paralyzed patients regained the ability to walk, prompting official Phase I clinical trials to b
The SUPER-FIN randomized trial reveals that cast immobilization is a viable, non-inferior alternative to surgery for unstable Weber B ankle fractures with a congruent mortise, leading to fewer complications and avoiding unnecessary hardware
The RESOLVE trial demonstrates that graded sensorimotor retraining provides modest pain relief for chronic low back pain. A secondary analysis reveals that these benefits are consistent across most patient subgroups, suggesting that the int
The ROXI-VTE trials demonstrate that inhibiting the Factor XI catalytic domain significantly reduces postoperative VTE compared to enoxaparin. While blocking Factor XIIa-mediated activation showed promise, it failed to meet superiority, hig
The RESTORE trial’s 3-year follow-up reveals that Cognitive Functional Therapy (CFT) provides sustained reductions in disability and pain for chronic low back pain compared to usual care, offering a transformative, evidence-based appr
The CLEAT trial demonstrates that an 8-week cycling and education program (CHAIN) significantly improves function in hip osteoarthritis compared to usual physiotherapy. Despite falling just short of the clinical importance threshold, its hi
A groundbreaking clinical trial explores whether injecting steroids into the knee’s infrapatellar fat pad can alleviate pain and protect cartilage. While primary pain targets weren’t met, the secondary findings offer a fascinating gli
The PACBACK randomized trial reveals that clinician-supported biopsychosocial self-management significantly reduces one-year disability in patients with acute low back pain at high risk of chronicity, whereas spinal manipulation alone offer
The 10-year FIMPACT trial results confirm that arthroscopic subacromial decompression (ASD) provides no superior relief for subacromial pain syndrome compared to placebo surgery or exercise therapy, fundamentally challenging traditional sur
Low-certainty evidence suggests cryotherapy may slightly reduce blood loss, pain, and swelling after total knee replacement, but clinical relevance remains uncertain.
The 10-year TOPKAT randomized trial found no clinically important difference in Oxford Knee Score between partial (PKR) and total knee replacement (TKR) for medial compartment osteoarthritis, similar revision/reoperation rates, and cost-eff
In a large single‑institution cohort of oropharyngeal squamous cell carcinoma, proton therapy was associated with a higher 3‑year rate of osteoradionecrosis than IMRT (6.4% vs 2.7%), though severe ORN remained uncommon.
The APPROACH randomized trial found once-weekly navepegritide significantly increased annualized growth velocity and produced favorable skeletal alignment and physical-function improvements in children with achondroplasia, with an acceptabl
A 12-year-old female with primary failure of eruption (PFE) affecting the right mandibular first molar is treated successfully via extraction and orthodontic repositioning, restoring function and occlusion.
A pooled prospective analysis of 18,935 hips found severe pincer morphology (LCEA ≥45°) was associated with a 1.5-fold higher odds of incident radiographic hip osteoarthritis within 8 years; moderate pincer (LCEA ≥40°) showed no overall ass
