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Economic evaluation shows direct mailing of HPV self-sampling kits improves cervical cancer screening completion and is cost-effective among varied screening history groups in a US healthcare system, with budget benefits over time.
A comprehensive analysis reveals that menopause does not significantly alter the risk of disability progression in women with relapse-onset multiple sclerosis, underscoring the complexity of reproductive aging’s role in disease trajec
Seventeen years after HPV vaccine introduction, substantial reductions in vaccine-type HPV prevalence confirm strong effectiveness and herd protection among vaccinated and unvaccinated sexually experienced adolescent girls and young women a
This multicenter randomized trial demonstrates that antenatal betamethasone significantly lowers severe respiratory morbidity in late preterm twin neonates, offering evidence-based guidance for managing twin pregnancies at imminent preterm
Breast cancer screening among older US women shows stable use but rising costs driven by low-value technologies; optimizing screening strategies could enhance value and reduce expenditure.
The PORTEC-3 trial demonstrates that adding platinum-based chemotherapy to pelvic radiotherapy significantly improves 10-year overall and recurrence-free survival in high-risk endometrial cancer, especially in patients with p53 abnormal tum
This study evaluates how pregnancy affects relapse rates and long-term disability in women with moderate to severe multiple sclerosis (MS), showing pregnancy reduces relapse during gestation without worsening long-term disability progressio
This study reveals that among women aged 65 and older with early-stage cervical cancer, those who receive recommended treatment—surgery and/or radiotherapy—exhibit significantly higher survival rates, emphasizing the need to overcome treatm
Pregnant individuals with insomnia or obstructive sleep apnea face significantly increased risks of ischemic placental disease, severe maternal morbidity, and preterm birth, highlighting the critical need for early detection and interventio
Physician peer influence significantly increases the adoption of opportunistic salpingectomy during postpartum and interval tubal sterilizations, enhancing ovarian cancer prevention.
The PASSIoN study shows that intranasally administered allogeneic mesenchymal stromal cells in neonates with perinatal arterial ischemic stroke are safe up to two years and suggest better motor outcomes compared to untreated cohorts.
The pilot PARTUM trial demonstrates the feasibility of a large-scale multi-national randomized study assessing low-dose aspirin versus placebo for postpartum venous thromboembolism prevention in moderate-risk individuals, supporting further
The IMPACT trial demonstrates that adding certolizumab pegol to standard therapy reduces placenta-mediated adverse pregnancy outcomes in women with antiphospholipid syndrome and lupus anticoagulant, with favorable safety and neonatal outcom
Early low-dose aspirin reduces early preterm birth risk and delays timing of delivery in women at high risk for preterm pre-eclampsia, with significant benefits in iatrogenic preterm births and small-for-gestational-age pregnancies.
This RCT compares nifedipine GITS 30 mg twice daily versus 60 mg once daily in severe preeclampsia, finding similar blood pressure control but fewer emergent treatments with twice-daily dosing, informing safer antihypertensive strategies in
Scientific evidence highlights coenzyme Q10 supplementation as a promising intervention to combat ovarian aging, improve oocyte quality, and enhance female fertility, especially for women over 35 or with compromised ovarian reserve.
A 12-week randomized trial demonstrates that combining metformin and nanocurcumin significantly improves lipid metabolism, glucose regulation, hormonal balance, and body metrics in women with PCOS, surpassing effects seen with either agent
The ENDOLA trial explored olaparib with metronomic cyclophosphamide and metformin, demonstrating a favorable safety profile and promising efficacy in heavily pretreated recurrent endometrial cancer patients, highlighting molecular subtype-d
This review synthesizes recent evidence on metformin’s therapeutic and prognostic roles in cervical, ovarian, and endometrial cancers, highlighting randomized trials, meta-analyses, and clinical outcomes with a focus on progression-fr
This phase II study shows that adding metformin to standard chemoradiotherapy in locally advanced cervical cancer is safe, well tolerated, and feasible, with no significant increase in severe adverse events and successful biomarker-based tu
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