Family History Misses Actionable Germline Variants in Many Ovarian Cancer Patients Over 70
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In more than 113,000 ovarian cancer patients undergoing germline testing, 6.6% of those aged 70 years or older carried pathogenic or likely pathogenic variants in established ovarian cancer susceptibility genes.
Older patients were about 1.5-fold less likely to report a family history of cancer, suggesting that family-history-based referral strategies lose sensitivity with age.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.