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A prospective study of 1071 couples identifies that plasma trace metal concentrations in both partners significantly influence IVF success, with elements like iron and molybdenum showing benefits while silver and thallium pose risks to embr
A cross-sectional study reveals that 26% of women with Type 1 Diabetes suffer from undiagnosed androgen excess, primarily PCOS. The findings emphasize the role of iatrogenic hyperinsulinism and advocate for routine screening, especially for
This review synthesizes recent clinical evidence identifying novel per- and poly-fluoroalkyl substances (PFAS) as significant risk factors for premature ovarian insufficiency (POI), highlighting their impact on ovarian reserve markers and e
A pooled analysis of 1,746 patients demonstrates that while fresh cycle success peaks early, cumulative live birth rates continue to rise with oocyte yield, plateauing at 21–25 oocytes. This benefit is most pronounced in patients aged 38 an
An international multicenter study confirms that endometrial thickness below 7 mm reduces live birth rates in most frozen embryo transfer protocols, though the impact is notably absent in natural cycles and overall predictive power remains
A large-scale analysis of over 16,000 cases reveals that endometrial compaction following progesterone administration does not improve pregnancy outcomes in HRT-FET, and may even be associated with lower success rates in blastocyst transfer
A multicentric study demonstrates that sex-steroid levels on the day of embryo transfer do not predict live birth rates in a novel programmed-ovulatory FET protocol using dydrogesterone, suggesting that routine hormonal monitoring may be un
A large-scale cohort study emulating randomized trials indicates that benzodiazepine use during pregnancy significantly increases the risk of abortion and preterm birth, even after accounting for competing risks and maternal factors. Risks
A secondary analysis of the multicentre INVICSI RCT reveals that ICSI results in fewer high-quality Day 5 blastocysts compared to conventional IVF in patients without severe male factor infertility, with no significant differences observed
A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are c
Thyroid cancer treatments in young women are linked to increased infertility diagnosis and early menopause but show no significant association with premature ovarian insufficiency or reduced childbirth rates.
A nationwide cohort study demonstrates that maternal pre-existing ASCVD is independently associated with an increased risk of neonatal complications and long-term neurodevelopmental disorders, persisting regardless of adverse pregnancy outc
This study introduces a novel method using parental and cell-division origin analysis to reduce false-positive mosaic embryo diagnoses in preimplantation genetic testing, improving embryo selection and transfer outcomes.
A large, double-blinded study reveals that reporting embryo mosaicism (ICN) during PGT-A provides no meaningful clinical predictive value for live birth rates, suggesting that current classification systems may unnecessarily limit embryo se
A landmark study establishes a data-driven diagnostic threshold for high tone pelvic floor dysfunction (HTPFD), identifying a summative tenderness score of >12/60 as a key clinical marker associated with persistent pain, activity-induced
A large-scale analysis of over 83,000 cases reveals that laparoscopic hysterectomy may offer lower complication rates and shorter hospital stays than vaginal hysterectomy, prompting a re-evaluation of current surgical guidelines for benign
This study identifies key modifiable surgical and hospital-level factors—including surgical approach and antibiotic adherence—that contribute to the disproportionately higher rate of postoperative complications experienced by Black patients
Pregnant women show increased risk of long COVID-19 post-SARS-CoV-2 infection during Omicron predominance despite mild disease, yet incidence remains modest in a highly vaccinated cohort, highlighting vaccination’s protective role amidst em
Vaccination against SARS-CoV-2 during pregnancy significantly lowers risks of severe maternal COVID-19, hospitalization, critical care admission, and preterm birth across variant periods, underscoring its safety and efficacy for maternal an
The French GR2 prospective study reveals that while 91% of pregnancies in systemic sclerosis result in livebirths, patients face significantly higher risks of pre-eclampsia, fetal growth restriction, and severe postpartum hemorrhage, with n
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