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The UMC‑UPPERGI‑01 randomized trial (n=208) found laparoscopic distal gastrectomy with D2 lymphadenectomy had similar 30‑day morbidity and mortality to open surgery for clinical T4a gastric cancer, despite longer operative times and modestl
Interim results from the phase 2 PHERFLOT trial show a 48.4% pathological complete response and a 67.7% major pathologic response after four cycles of pembrolizumab, trastuzumab and FLOT in localized HER2‑positive esophagogastric adenocarci
In high–cardiac-risk veterans after major vascular or general surgery, a liberal postoperative transfusion threshold (Hb <10 g/dL) did not reduce 90‑day death or major ischemic events compared with a restrictive threshold (Hb <7 g/dL)
A multicenter randomized trial shows electroacupuncture (EA) reduces time to first flatus and defecation and lowers prolonged POI after laparoscopic gastrectomy. Mechanistic plausibility, ERAS integration, and implementation challenges are
A multicentre randomized trial found EUS-guided gastroenterostomy (EUS-GE) superior to surgical gastrojejunostomy (SGJ) for malignant gastric outlet obstruction—improving oral intake, shortening hospital stay, enhancing quality of life and
A multicentre randomized trial (NCT05548114) found endoscopic ultrasound‑guided gastroenterostomy (EUS‑GE) superior to surgical gastrojejunostomy (SGJ) for malignant gastric outlet obstruction, with faster return to solid diet, shorter hosp
The ReCePI randomized phase 3 trial found that amustaline/glutathione pathogen-reduced red blood cells produced similar rates of acute kidney injury compared with conventional transfusion after cardiac or thoracic-aorta surgery, with few tr
This Canadian multicenter study evaluates liver transplant outcomes using grafts from donation after medical assistance in dying donors, showing comparable survival and complication rates to standard donors and increasing transplant activit
This landmark study reports the first successful genetically engineered pig auxiliary liver transplanted into a living human, revealing critical insights on immunological compatibility and post-transplant complications, advancing liver xeno
An international study reveals that postoperative vasopressor infusions after noncardiac surgery vary widely across hospitals and are linked to higher mortality and complications, highlighting the need for optimized management strategies.
Combining liver transplant with sleeve gastrectomy yields sustained weight loss, improved metabolic syndrome, and reduced liver allograft steatosis, without increasing mortality or graft loss, offering an effective treatment for obese patie
A large retrospective cohort study reveals bariatric surgery markedly lowers the incidence of key metabolic comorbidities compared to weight management alone in obese veterans, supporting its role in durable obesity-related risk reduction.
This network meta-analysis of 49 RCTs demonstrates that digital health interventions, notably virtual reality, 2D videos, and 2D games, significantly reduce perioperative anxiety and pain and improve induction compliance in pediatric surgic
The MERLIN_001 study validates a combined clinicopathological and gene expression profile test that accurately predicts sentinel lymph node metastasis risk in patients with cutaneous melanoma, potentially guiding safer, more personalized su
This article reviews 12 evidence-backed strategies to enhance sustainability in gynecologic surgery by minimizing single-use disposables and reducing carbon emissions in the operating room.
Recent advances in genetically modified pig-to-human organ transplantation offer promising solutions for acute liver failure, bridging critical gaps in organ availability and raising important ethical and regulatory considerations.
A large multicenter study finds no association between fentanyl administration and failed reduction of pediatric ileocolic intussusception, supporting its safe use for analgesia during the painful reduction procedure.
The SIPS surgical handover system significantly improves handover quality, patient vital signs, and staff safety perceptions without prolonging meeting times, enhancing safety in emergency general surgery.
Early extracranial surgery following moderate-severe traumatic brain injury or positive CT findings is linked to worse cognitive, functional, and quality of life outcomes at one year, highlighting the need to refine surgical timing and post
This retrospective national cohort study reveals that Medicare Advantage (MA) enrollees undergoing major cancer surgery are less likely to receive care at high-quality hospitals compared to traditional Medicare beneficiaries, raising concer
