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A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-rel
Emerging RCT evidence supports Tai Chi’s superior benefits over fitness walking in improving cognitive function and sleep quality among older adults with type 2 diabetes and mild cognitive impairment, facilitated by telemedicine and w
This study evaluated the antidepressant effects of a Lactobacillus probiotic in overweight depressed patients with systemic low-grade inflammation, revealing no overall benefit but highlighting fecal formic acid as a potential biomarker for
A 3-month RCT demonstrates that multi-species probiotic supplementation improves vagal nerve function, gut microbiome composition, and sleep quality in patients with major depression, suggesting novel gut-brain axis interventions.
Combining aerobic and resistance exercise with diet-induced weight loss in older adults with obesity significantly improves insulin secretion, metabolic health, and physical function, likely mediated by ciliary neurotrophic factor receptor
A fermentable carbohydrate-enriched diet combined with metformin improves postprandial glycaemia, enhances GLP-1 secretion, and positively alters gut microbiota in prediabetic individuals, offering a personalized nutrition-pharmacology stra
A one-year DASH diet intervention led to sustained suppression of proatherogenic chemokine CXCL4 and fewer major cardiovascular events over six years despite reduced adherence and partial loss of initial benefits in nonobstructive CAD patie
Intraduodenal calcium at doses up to 1000 mg amplifies the anorexigenic effects of L-tryptophan by boosting gut hormones CCK, GLP-1, and PYY, reducing energy intake in obese males, highlighting a novel adjunctive approach for appetite regul
This study explores how caloric restriction influences organ size and metabolic adaptation, using MRI data from the CALERIE 2 trial, revealing nuanced changes in energy expenditure linked to organ-specific tissue loss.
A 4-week anti-inflammatory dietary intervention in knee osteoarthritis patients led to targeted shifts in gut microbiota and metabolite profiles associated with significant pain reduction, highlighting the potential of microbiome-informed n
The MEDEA randomized trial demonstrated that a multifactorial diet reduces plasma ApoC-III, correlates with decreased liver and pancreatic fat, and improves beta cell function in type 2 diabetes compared to a MUFA-rich diet.
Recent research reveals that high-fat diets rich in olive oil, while not impairing immunity, significantly promote lung metastasis of triple-negative breast cancer via a novel fatty acid-driven mechanism involving FABP5 and ALDH pathways.
A 17-week randomized controlled trial demonstrates that a high-protein diet combined with strength training does not negatively affect oxidative stress markers in older adults, supporting their safe use to combat sarcopenia.
Afternoon high-intensity interval exercise improves post-exercise blood glucose and reduces inflammation more effectively than morning sessions in type 2 diabetes, highlighting circadian influences on exercise metabolism and benefits of mea
A prespecified subanalysis of the PACMAN-HF trial demonstrates that individualized nutritional interventions in chronic heart failure patients at risk of malnutrition improve nutritional status and functional capacity but do not significant
A randomized trial investigating time-restricted eating and exercise before and during pregnancy found no significant improvement in glucose tolerance at 28 weeks gestation among individuals at elevated risk of gestational diabetes.
Short-term alterations in dietary energy intake significantly impact fecal serotonin, gut microbiome tryptophanase activity, and energy absorption, highlighting a complex interaction that may influence metabolic health.
Daily blueberry intake during complementary feeding may enhance allergy symptom resolution, favorably influence immune biomarkers, and promote beneficial gut microbiota shifts in breastfed infants, suggesting new avenues for allergy prevent
A randomized crossover trial shows that daily intake of 40 g walnuts increases urinary 6-sulfatoxymelatonin, reduces sleep latency, and improves global sleep quality in young adults, highlighting walnuts’ potential as a natural sleep
The MeMeMe randomized trial shows that metformin 1,700 mg/day effectively prevents type 2 diabetes in metabolic syndrome patients, independent of Mediterranean diet adherence, with implications for age-related disease prevention.
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