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A randomized controlled crossover trial found that individualized exclusion diets based on confocal laser endomicroscopy (CLE) findings do not significantly improve symptoms in irritable bowel syndrome (IBS) patients compared to sham diets.
The EVER trial examined if a structured early mobilization protocol improves functional outcomes in ventilated patients with sepsis or respiratory failure. Despite earlier and increased mobilization, no significant functional benefit was ob
A nurse-led, mobile health-supported collaborative care intervention significantly increased days alive and out of hospital and reduced mortality among Indian patients with heart failure with reduced ejection fraction over 2 years.
This multicentre RCT demonstrates that perioperative vaginal oestrogen therapy improves patient-reported symptom relief and pelvic floor quality of life at 12 months post-prolapse surgery in postmenopausal women, without changing anatomical
The TRANSPORT trial showed no superiority of liberal versus restrictive RBC transfusion in septic shock patients with cancer, highlighting no mortality benefit and increased thrombotic events with liberal strategy, underscoring the need for
The MIPI trial demonstrates that preemptive multidose ibuprofen substantially reduces pain during intrauterine device (IUD) insertion, highlighting a practical approach to enhance patient comfort and potentially increase IUD acceptability.
The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement
First MTPJ arthrodesis significantly reduces walking pain at 12 months in hallux rigidus patients compared with watchful waiting, demonstrating a clinically meaningful benefit in this common foot osteoarthritis.
A recent randomized controlled trial demonstrates that nonopioid analgesia is noninferior to routine opioid prescribing for pain control after minimally invasive hysterectomy, with high patient satisfaction and markedly reduced opioid use.
A multicentre RCT found that smartphone-based self-guided hypnotherapy did not meet non-inferiority to in-person therapy for IBS abdominal pain, though both hypnotherapy arms outperformed psychoeducation.
The WONDER-01 trial found that immediate endoscopic necrosectomy after drainage for necrotizing pancreatitis reduced median time to clinical success by 15 days compared to a step-up approach, with similar adverse events.
A 10-year follow-up of a randomized trial comparing conservative nodule excision with segmental resection for rectal endometriosis reveals comparable long-term functional outcomes, low recurrence rates, and sustained symptomatic relief.
The ORBITA-CTO multicenter, randomized, placebo-controlled trial demonstrates that PCI significantly improves angina symptoms and quality of life in patients with single-vessel CTO without bystander disease, compared to placebo.
This review synthesizes evidence from the WAFER trial and related studies comparing WALANT to GA/RA in flexor tendon repair, highlighting functional outcomes, safety, cost-effectiveness, and patient-centered benefits including earlier retur
The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.
Menaquinone-7 (MK-7) supplementation over two years significantly slows progression of coronary artery calcification (CAC) in symptomatic coronary artery disease patients, with favorable safety and potential implications for plaque stabiliz
A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.
A pooled individual participant data meta-analysis demonstrates that Electromagnetic Network-Targeted Field (ENTF) neuromodulation significantly improves freedom-from-disability and reduces poststroke disability compared to sham treatment,
A 2026 RCT assessed telehealth stepped alcohol treatment in chronic liver disease patients, finding significant reductions in weekly alcohol consumption but no difference in achieving moderate drinking levels compared to usual care.
A multicenter RCT shows proactive home fecal calprotectin monitoring without protocolized treatment escalation does not reduce symptomatic flares in ulcerative colitis remission. More research is needed to optimize biomarker-guided manageme
