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Enhancing Survivorship: Multidisciplinary Rehabilitation Improves Cardiorespiratory Fitness in Upper Gastrointestinal Cancer Surgery Patients
General Surgerycardiorespiratory fitnessmultidisciplinary rehabilitation

Enhancing Survivorship: Multidisciplinary Rehabilitation Improves Cardiorespiratory Fitness in Upper Gastrointestinal Cancer Surgery Patients

By MedXY|Sep 17, 2026

RESTORE II RCT demonstrates that a 12-week multidisciplinary rehabilitation program significantly improves cardiorespiratory fitness in survivors of upper gastrointestinal cancer surgery, supporting its integration in post-oncologic care.

Harnessing Multidomain Baseline Metrics to Predict Attrition in Diabetic Foot Ulcer Offloading Trials
Diabetes & Endocrinology
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Contact usAbout usPrivacy PolicyMedXY story
offloading devices
attrition prediction

Harnessing Multidomain Baseline Metrics to Predict Attrition in Diabetic Foot Ulcer Offloading Trials

By MedXY|Sep 8, 2026

Baseline clinical, functional, and psychosocial metrics predict participant attrition in diabetic foot ulcer offloading device trials; integration via risk visualization enhances retention strategies and highlights technology benefits.

Negative Pressure Therapy in Major Lower Extremity Amputation: A Critical Review of Current Randomized Controlled Trials
Clinical Updateslower extremity amputationnegative pressure therapy

Negative Pressure Therapy in Major Lower Extremity Amputation: A Critical Review of Current Randomized Controlled Trials

By MedXY|Sep 5, 2026

This review synthesizes evidence from recent randomized controlled trials assessing negative pressure therapy (NPT) for reducing wound complications after major lower extremity amputation, highlighting variable efficacy and potential benefi

Enhancing Sexual and Pelvic Health in Women: Efficacy of Scheduled Vibrator Use in a Randomized Controlled Trial
newssexual dysfunctionpelvic floor disorders

Enhancing Sexual and Pelvic Health in Women: Efficacy of Scheduled Vibrator Use in a Randomized Controlled Trial

By MedXY|Sep 5, 2026

Scheduled vibrator use combined with educational support significantly improves sexual function in women with sexual dysfunction and pelvic floor disorders compared to education alone.

Confocal Laser Endomicroscopy-Guided Exclusion Diet Fails to Improve IBS Symptoms in Controlled Trial
GastroenterologyIrritable Bowel SyndromeConfocal Laser Endomicroscopy

Confocal Laser Endomicroscopy-Guided Exclusion Diet Fails to Improve IBS Symptoms in Controlled Trial

By MedXY|Sep 5, 2026

A randomized controlled crossover trial found that individualized exclusion diets based on confocal laser endomicroscopy (CLE) findings do not significantly improve symptoms in irritable bowel syndrome (IBS) patients compared to sham diets.

Evaluating the Impact of Early Mobilization in Mechanically Ventilated ICU Patients with Sepsis or Acute Respiratory Failure: Insights from the EVER Multicenter RCT
Critical CaresepsisICU rehabilitation

Evaluating the Impact of Early Mobilization in Mechanically Ventilated ICU Patients with Sepsis or Acute Respiratory Failure: Insights from the EVER Multicenter RCT

By MedXY|Sep 6, 2026

The EVER trial examined if a structured early mobilization protocol improves functional outcomes in ventilated patients with sepsis or respiratory failure. Despite earlier and increased mobilization, no significant functional benefit was ob

Improving Heart Failure Outcomes in India: Evidence from the TIME-HF Nurse-Coordinated, Digital-Supported Care Model Trial
Cardiologyheart failuredigital health

Improving Heart Failure Outcomes in India: Evidence from the TIME-HF Nurse-Coordinated, Digital-Supported Care Model Trial

By MedXY|Sep 1, 2026

A nurse-led, mobile health-supported collaborative care intervention significantly increased days alive and out of hospital and reduced mortality among Indian patients with heart failure with reduced ejection fraction over 2 years.

Vaginal Oestrogen Therapy Enhances Symptomatic Recovery After Prolapse Surgery in Postmenopausal Women: Insights from a Multicentre RCT
newspostmenopausal womenprolapse surgery

Vaginal Oestrogen Therapy Enhances Symptomatic Recovery After Prolapse Surgery in Postmenopausal Women: Insights from a Multicentre RCT

By MedXY|Aug 31, 2026

This multicentre RCT demonstrates that perioperative vaginal oestrogen therapy improves patient-reported symptom relief and pelvic floor quality of life at 12 months post-prolapse surgery in postmenopausal women, without changing anatomical

Early Red Blood Cell Transfusion Strategy in Septic Shock Among Cancer Patients: Insights from the TRANSPORT Randomized Controlled Trial
Clinical UpdatesRed Blood Cell Transfusionseptic shock

Early Red Blood Cell Transfusion Strategy in Septic Shock Among Cancer Patients: Insights from the TRANSPORT Randomized Controlled Trial

By MedXY|Aug 27, 2026

The TRANSPORT trial showed no superiority of liberal versus restrictive RBC transfusion in septic shock patients with cancer, highlighting no mortality benefit and increased thrombotic events with liberal strategy, underscoring the need for

Multidose Ibuprofen Significantly Alleviates Pain During Intrauterine Device Insertion: Insights from the MIPI Trial
newspain managementibuprofen

Multidose Ibuprofen Significantly Alleviates Pain During Intrauterine Device Insertion: Insights from the MIPI Trial

By MedXY|Aug 18, 2026

The MIPI trial demonstrates that preemptive multidose ibuprofen substantially reduces pain during intrauterine device (IUD) insertion, highlighting a practical approach to enhance patient comfort and potentially increase IUD acceptability.

Neurological Effects and Safety of Encapsulated Dexamethasone Sodium Phosphate in Pediatric Ataxia Telangiectasia: Insights from the NEAT Phase 3 Trial
Clinical Updatesataxia-telangiectasiaencapsulated dexamethasone

Neurological Effects and Safety of Encapsulated Dexamethasone Sodium Phosphate in Pediatric Ataxia Telangiectasia: Insights from the NEAT Phase 3 Trial

By MedXY|Aug 17, 2026

The NEAT phase 3 trial evaluated erythrocyte-encapsulated dexamethasone sodium phosphate in children with ataxia telangiectasia aged 6–9 years, confirming safety but failing to demonstrate statistically significant neurological improvement

Surgical Arthrodesis Versus Watchful Waiting in Hallux Rigidus: Insights from a Landmark Randomized Controlled Trial
newsarthrodesismetatarsophalangeal joint

Surgical Arthrodesis Versus Watchful Waiting in Hallux Rigidus: Insights from a Landmark Randomized Controlled Trial

By MedXY|Aug 12, 2026

First MTPJ arthrodesis significantly reduces walking pain at 12 months in hallux rigidus patients compared with watchful waiting, demonstrating a clinically meaningful benefit in this common foot osteoarthritis.

Nonopioid vs Opioid Pain Management After Laparoscopic Hysterectomy: A Noninferiority Randomized Trial
AnesthesiologyLaparoscopic Hysterectomyrandomized controlled trial

Nonopioid vs Opioid Pain Management After Laparoscopic Hysterectomy: A Noninferiority Randomized Trial

By MedXY|Aug 18, 2026

A recent randomized controlled trial demonstrates that nonopioid analgesia is noninferior to routine opioid prescribing for pain control after minimally invasive hysterectomy, with high patient satisfaction and markedly reduced opioid use.

Can a smartphone app replace in-person hypnotherapy for IBS? Trial finds non-inferiority not demonstrated, but response rates suggest a viable alternative
GastroenterologyIBSrandomized controlled trial

Can a smartphone app replace in-person hypnotherapy for IBS? Trial finds non-inferiority not demonstrated, but response rates suggest a viable alternative

By MedXY|Jul 28, 2026

A multicentre RCT found that smartphone-based self-guided hypnotherapy did not meet non-inferiority to in-person therapy for IBS abdominal pain, though both hypnotherapy arms outperformed psychoeducation.

Immediate Endoscopic Necrosectomy Shortens Recovery Time in Necrotizing Pancreatitis Without Increasing Complications
Gastroenterologyendoscopic necrosectomyrandomized controlled trial

Immediate Endoscopic Necrosectomy Shortens Recovery Time in Necrotizing Pancreatitis Without Increasing Complications

By MedXY|Jul 26, 2026

The WONDER-01 trial found that immediate endoscopic necrosectomy after drainage for necrotizing pancreatitis reduced median time to clinical success by 15 days compared to a step-up approach, with similar adverse events.

Decade-Long Outcomes of Surgical Options in Rectal Endometriosis: Insights from a Robust Randomized Trial
General Surgerylong-term outcomesRectal Endometriosis

Decade-Long Outcomes of Surgical Options in Rectal Endometriosis: Insights from a Robust Randomized Trial

By MedXY|Aug 18, 2026

A 10-year follow-up of a randomized trial comparing conservative nodule excision with segmental resection for rectal endometriosis reveals comparable long-term functional outcomes, low recurrence rates, and sustained symptomatic relief.

ORBITA-CTO Trial: Evaluating the Impact of Percutaneous Coronary Intervention on Symptomatic Chronic Total Occlusion in Stable Angina
Cardiologychronic total occlusionPercutaneous Coronary Intervention

ORBITA-CTO Trial: Evaluating the Impact of Percutaneous Coronary Intervention on Symptomatic Chronic Total Occlusion in Stable Angina

By MedXY|Jul 14, 2026

The ORBITA-CTO multicenter, randomized, placebo-controlled trial demonstrates that PCI significantly improves angina symptoms and quality of life in patients with single-vessel CTO without bystander disease, compared to placebo.

WAFER Trial and Beyond: Comparative Efficacy and Pragmatic Implications of WALANT versus General and Regional Anesthesia in Flexor Tendon Repair
AnesthesiologyAnesthesiaflexor tendon repair

WAFER Trial and Beyond: Comparative Efficacy and Pragmatic Implications of WALANT versus General and Regional Anesthesia in Flexor Tendon Repair

By MedXY|Jul 12, 2026

This review synthesizes evidence from the WAFER trial and related studies comparing WALANT to GA/RA in flexor tendon repair, highlighting functional outcomes, safety, cost-effectiveness, and patient-centered benefits including earlier retur

Integrating Trauma-Focused Therapy with Cognitive Behavioural Therapy for Psychosis: Insights from the STAR Trial and Related Research
Clinical UpdatesCBTpPsychosis

Integrating Trauma-Focused Therapy with Cognitive Behavioural Therapy for Psychosis: Insights from the STAR Trial and Related Research

By MedXY|Jul 12, 2026

The STAR trial demonstrates that trauma-focused CBTp is a safe, effective intervention for adults with co-occurring PTSD and psychosis, improving PTSD and psychosis symptoms, with high acceptability and minimal adverse events.

Two Years of Menaquinone-7 Supplementation Attenuates Coronary Artery Calcification Progression: Evidence from Randomized Clinical Trials
Cardiologycoronary artery calcificationmenaquinone-7

Two Years of Menaquinone-7 Supplementation Attenuates Coronary Artery Calcification Progression: Evidence from Randomized Clinical Trials

By MedXY|Jul 4, 2026

Menaquinone-7 (MK-7) supplementation over two years significantly slows progression of coronary artery calcification (CAC) in symptomatic coronary artery disease patients, with favorable safety and potential implications for plaque stabiliz

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