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A multicenter RCT demonstrates that a standardized clinical pathway for platelet-rich plasma therapy improves 12-month pain and function outcomes with fewer adverse events in early knee osteoarthritis compared to conventional care.
A randomized trial shows that intraoperative Lugol’s iodine staining during LEEP increases positive resection margins and should not be routinely applied, despite reducing postoperative bleeding duration.
The DANCODE trial demonstrates that combined vitamin K2 and D3 supplementation reduces the progression of severe coronary artery calcification over 24 months without increasing noncalcified plaque burden, offering a promising adjunctive str
The LAST-long trial investigated a community-based, individualized stroke intervention and found that age—but not frailty—significantly modifies its effectiveness, with older stroke survivors (≥80 years) experiencing less favorable outcomes
An 8-week smartphone-based digital therapeutic offering personalized exercise and cognitive-behavioural therapy significantly improved pain, knee function, quality of life, and psychological outcomes in patients with chronic patellofemoral
A pragmatic RCT suggests that exercise following spinal cord injury guidelines may reduce chronic pain intensity, with significant benefits observed in pain interference and coping strategies.
A pilot double-blind RCT suggests that adding a single ultrasound-guided dextrose prolotherapy injection to therapeutic exercise moderately improves shoulder pain and function in adults with subacromial-subdeltoid bursitis.
A six-month supervised telerehabilitation programme combining Pilates-based exercises and self-myofascial release significantly improved fibromyalgia impact, sleep quality, depressive symptoms, and stress levels compared to usual care in ad
A German randomized controlled trial demonstrates that Modified Psychodynamic Psychotherapy for Schizophrenia (MPP-S) combined with standard care significantly improves psychosocial functioning over two to three years compared to standard c
A randomized trial found no significant benefit of early specialist palliative care on end-of-life outcomes among patients undergoing curative abdominal cancer surgery, suggesting tailored rather than routine involvement.
A randomized trial found no significant difference in delayed gastric emptying rates between side-to-side and end-to-side gastrojejunostomy after pancreatoduodenectomy, with comparable postoperative outcomes and quality of life.
The IPAD randomized trial shows no significant difference in delayed gastric emptying rates between side-to-side and end-to-side gastrojejunostomy after pancreatoduodenectomy, with comparable postoperative outcomes and quality of life.
This review synthesizes long-term immunogenicity data from a South African RCT comparing 1+1 and 2+1 infant PCV10 and PCV13 schedules. PCV13 1+1 schedules maintain durable immunity up to age 5, supporting schedule optimization in establishe
A hybrid RCT among 630 Latino caregiver-infant dyads demonstrates that text messaging and community resource referrals augment primary care literacy promotion, improving language, social-emotional development, and parenting behaviors.
A recent randomized clinical trial reveals that adjunctive intravenous ketamine significantly reduces depressive symptoms in treatment-resistant bipolar depression, with good safety and tolerability compared to midazolam.
A recent double-blind, placebo-controlled trial found that non-enteric-coated pancreatic enzyme therapy does not significantly reduce pain in chronic pancreatitis patients, highlighting the need to revisit pain management strategies in this
RESTORE II RCT demonstrates that a 12-week multidisciplinary rehabilitation program significantly improves cardiorespiratory fitness in survivors of upper gastrointestinal cancer surgery, supporting its integration in post-oncologic care.
Baseline clinical, functional, and psychosocial metrics predict participant attrition in diabetic foot ulcer offloading device trials; integration via risk visualization enhances retention strategies and highlights technology benefits.
This review synthesizes evidence from recent randomized controlled trials assessing negative pressure therapy (NPT) for reducing wound complications after major lower extremity amputation, highlighting variable efficacy and potential benefi
Scheduled vibrator use combined with educational support significantly improves sexual function in women with sexual dysfunction and pelvic floor disorders compared to education alone.
