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A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety out
A multicentre randomized trial evaluated adjunctive corticosteroids in HIV-negative severe Pneumocystis jirovecii pneumonia, showing a non-significant reduction in 28-day mortality and no safety concerns, and calls for further targeted rese
A 28-day RCT demonstrates that a conversational AI trained on a large language model effectively reduces mild depression and anxiety symptoms in young adults through dialog interventions integrated in short video apps.
Automated insulin delivery (AID) significantly improves glycemic control in insulin-treated type 2 diabetes, demonstrating greater HbA1c reduction and increased time in target glucose range compared to traditional insulin delivery methods.
This RCT assessed a proactive e-health intervention for patients with at-risk alcohol use and depressive symptoms, showing high adherence but only small, non-significant improvements at 12 months and no lasting effects at 24 months.
This phase 2 trial found no significant cognitive or behavioral benefits of rotigotine in bvFTD patients over 24 weeks, highlighting the challenges in dopaminergic therapy for frontotemporal dementia.
This review synthesizes evidence from the CSPACE RCT demonstrating superior clinical outcomes of conduction system pacing over right ventricular septal pacing in AV block patients, emphasizing reduced pacing-induced cardiomyopathy and CRT u
This review synthesizes evidence on mobile digital therapeutics targeting vasomotor and behavioral health symptoms in menopausal and midlife women, highlighting efficacy, engagement, and implications for scalable symptom management.
This review synthesizes evidence from a multicenter RCT showing ALM-003 digital therapeutic reduces heavy drinking days significantly in alcohol-dependent individuals at high risk, with an excellent safety profile.
The TAP-IT trial found that additional thoracentesis in acute heart failure patients with pleural effusion did not improve days alive out of hospital, mortality, or length of stay compared to standard therapy alone.
A rigorous trial reveals that perceived symptom worsening from gluten or wheat in IBS patients may largely be driven by expectation rather than the substances themselves, underscoring the importance of distinguishing true sensitivities from
A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.
This study compares the effects of the Mediterranean diet and the Australian Guide to Healthy Eating (AGHE) on body composition and glucose metabolism, revealing significant benefits of the Mediterranean diet.
A 3-week ketogenic diet improved skeletal muscle insulin sensitivity and promoted weight loss in individuals with obesity, without significant effects on liver or adipose tissue insulin sensitivity.
A double-blind RCT found that three consecutive fecal microbiota transplantations did not significantly improve hepatic steatosis or metabolic parameters in patients with MASLD, suggesting patient selection based on microbiota diversity may
This trial evaluated low-dose hydrocortisone in cirrhotic patients with septic shock, finding no improvement in 28-day mortality or shock resolution compared to placebo.
A major RCT shows intermediate-dose cytarabine is noninferior to high-dose as postinduction therapy in AML, with similar survival and lower toxicity.
The DISTRICTS trial demonstrates that initial surgical treatment for carpal tunnel syndrome leads to significantly higher recovery rates at 18 months compared to starting with corticosteroid injections, despite similar adverse event profile
The DipGluMo trial found that real-time continuous glucose monitoring does not improve perinatal outcomes versus self-monitoring in gestational diabetes, but is preferred by patients for ease of use.
A UK multicentre, double-blind, placebo-controlled trial demonstrates that pramipexole augmentation at 2.5 mg reduces depressive symptoms in treatment-resistant unipolar depression at 12 weeks, with some adverse effects noted, supporting it