Tag
A 2026 PLOS One superiority trial found that internet-based vestibular rehabilitation was not superior to structured written instructions after acute vertigo. The result is clinically useful because the comparator was active, adherence was
Recent high-quality randomized clinical trials and meta-analyses suggest that routine magnesium sulfate infusion does not effectively prevent postoperative atrial fibrillation in cardiac surgery, especially when used alongside standard beta
In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.
A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.
A randomized trial in high-risk adults with type 2 diabetes found that proactive nurse-led care reduced severe hypoglycemia by about 50%, while adding psychoeducation did not significantly improve outcomes further.
A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.
The FreeDM2 trial demonstrates that real-time CGM significantly improves HbA1c levels compared to SMBG in adults with type 2 diabetes on basal insulin and modern therapies, with sustained benefits over 32 weeks.
A recent randomized controlled trial demonstrates that proximal hypoglossal nerve stimulation significantly improves obstructive sleep apnea symptoms in patients intolerant to positive airway pressure therapy.
The TREOCAPA randomized clinical trial demonstrates that while prophylactic intravenous acetaminophen effectively promotes patent ductus arteriosus closure in extremely preterm infants, it does not significantly increase survival without se
The NAPSACC UK cluster RCT found that a one-year environmental intervention in early childhood education settings did not significantly improve total energy consumption or physical activity, highlighting the need for broader policy-level ch
The SCIENCE multicentre randomized trial demonstrates that surgical fixation for displaced medial epicondyle fractures in children provides no functional advantage over non-surgical care, carries higher complication risks, and is not a cost
A 6-month randomized controlled trial reveals that varying dietary sweet taste exposure does not alter sweet taste liking, energy intake, or body weight, questioning the efficacy of public health recommendations to reduce sweet exposure for
Integrating tailored adherence support into exercise rehabilitation for vertebral fragility fractures significantly improves functional mobility and walking capacity compared to standard exercise alone at 12 months.
A large RCT in primary care showed no significant cognitive benefits of a combined intervention integrating mind-body physical exercise, cognitive training, and nurse-led risk factor modification over nurse-led risk factor modification alon
A large randomized controlled trial found that an Iyengar yoga-based exercise program increased fall rates among older adults compared to seated relaxation yoga, despite improvements in physical activity and balance confidence, highlighting
This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.
A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety out
A multicentre randomized trial evaluated adjunctive corticosteroids in HIV-negative severe Pneumocystis jirovecii pneumonia, showing a non-significant reduction in 28-day mortality and no safety concerns, and calls for further targeted rese
A 28-day RCT demonstrates that a conversational AI trained on a large language model effectively reduces mild depression and anxiety symptoms in young adults through dialog interventions integrated in short video apps.
Automated insulin delivery (AID) significantly improves glycemic control in insulin-treated type 2 diabetes, demonstrating greater HbA1c reduction and increased time in target glucose range compared to traditional insulin delivery methods.
