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Genetic analyses reveal that cholesteryl ester transfer protein (CETP) inhibition, while beneficial for cardiovascular disease, is associated with an increased risk of age-related macular degeneration (AMD) across European and East Asian po
This study reveals distinct structure-function correlations in early atrophic AMD, showing lesion size correlates with localized sensitivity loss, while lesion proximity to the fovea predicts central vision and reading outcomes, supporting
Intravitreal pegcetacoplan significantly slowed geographic atrophy progression by 41% over two years, maintaining efficacy in clinical practice for AMD patients, with stable visual acuity decline and manageable safety.
This study elucidates how ribbon-type reticular pseudodrusen, especially when coexisting with soft drusen, significantly impair retinal sensitivity in intermediate AMD, highlighting the importance of lesion phenotype in functional risk asse
Vision-related quality of life in geographic atrophy secondary to AMD is most strongly linked to lesion extent within a 2.5-mm central retinal zone, emphasizing targeted structural assessment for functional impact.
This study identifies three candidate geographic atrophy phenotypes in age-related macular degeneration, revealing distinct growth rates and severity, with implications for prognosis and clinical trials.
A 2026 expert consensus defines an image-based reference standard to validate AI screening algorithms for age-related macular degeneration (AMD), endorsing Beckman grading and routine OCT use while clarifying referral thresholds and areas o
This cohort study reveals that clonal hematopoiesis of indeterminate potential (CHIP) independently increases age-related macular degeneration (AMD) risk, with amplified effects when combined with high genetic susceptibility, especially in
Avacincaptad pegol significantly reduces progression of ellipsoid zone degradation and geographic atrophy lesion growth, highlighting its potential to preserve photoreceptor integrity in AMD patients.
This study evaluates the association of dopamine-enhancing drugs, especially levodopa, with lowered 3-year risk of progression from non-neovascular to neovascular AMD, offering promising insight into dopaminergic pathways in AMD management.
In patients with unilateral exudative AMD, double-layer sign on OCT was common, but OCT angiography showed nonexudative macular neovascularization in only about 40% of DLS-positive fellow eyes.
In a large TriNetX retrospective cohort, prescribed NSAID use was associated with a lower subsequent risk of AMD, including both non-exudative and exudative disease, though residual confounding limits causal inference.
A large retrospective cohort study reveals that GLP-1 receptor agonists significantly reduce the risk of developing nonexudative age-related macular degeneration in obese individuals without diabetes, with no effect on progression to exudat
This review synthesizes current evidence from large cohorts, meta-analyses, and randomized trials evaluating metformin’s association with AMD development and progression, highlighting a nuanced but inconclusive protective potential re
A large retrospective study found that diabetic patients using metformin for at least five consecutive years have a significantly lower risk of developing age-related macular degeneration, especially the dry type.
