Long-Term Metformin Use Linked to Reduced Risk of Age-Related Macular Degeneration in Diabetic Patients

Highlight

• Metformin use for 5 or more consecutive years was associated with a 32% reduced risk of developing AMD in diabetic patients.
• The protective effect was significant for dry AMD; a non-significant trend was observed in wet AMD.
• Statin use also correlated with decreased AMD risk, whereas insulin did not.
• Exclusion of patients with prior drusen attenuated protective associations, suggesting potential benefits throughout AMD progression.

Study Background and Disease Burden