Section
The phase 2 MIRA trial shows sonelokimab, an IL-17A/F-inhibiting nanobody, significantly improves outcomes in moderate-to-severe hidradenitis suppurativa with good tolerability compared to placebo.
This study evaluates wound healing and pain outcomes among PRF, PRGF, collagen-based dressing, and spontaneous healing in standardized palatal defects, revealing minimal added benefit from adjunctive treatments in healthy individuals.
Alopecia areata regrowth may present atypically with acquired curly hair texture, associated with pili torti ultrastructural changes, signifying a unique phenotype requiring clinical recognition.
The Cutaneous Lymphoma International Prognostic Index (CLIPI) enhances risk stratification and predicts progression and treatment response beyond conventional staging in advanced mycosis fungoides and Sézary syndrome.
Systemic relapse after stage I melanoma, though rare, portends higher tumor burden and poorer survival compared with relapse after stage II/III disease, as evidenced by data from 365 metastatic melanoma patients in the Spanish Melanoma Regi
This study presents a comprehensive single-cell RNA-sequencing atlas of CTCL, identifying oncogenic transcriptional programs and immune microenvironment features that offer new therapeutic targets for advanced-stage disease.
A randomized controlled trial demonstrates superior symptom relief with fractional CO2 laser treatment over topical clobetasol in women with vulvar lichen sclerosus, suggesting a novel therapeutic approach.
This study highlights dupilumab’s long-term effectiveness and safety in managing pediatric atopic dermatitis over 3 years, revealing age-related differences in symptom control and treatment persistence.
A retrospective series evaluating high-dose oral vitamin D demonstrated rapid improvement and symptom relief in patients with chemotherapy- and radiation-induced skin toxicity without adverse effects, supporting its potential role in oncode
This multicenter retrospective study identifies key baseline predictors influencing short-term remission and relapse in pemphigus patients treated with rituximab plus glucocorticoids, guiding personalized treatment strategies.
This analysis of the 4-year PEDISTAD registry reveals dupilumab’s superior effectiveness and comparable safety in treating moderate-to-severe atopic dermatitis in children across diverse racial groups.
This multicenter study identifies a unique pustular psoriasis flare phenotype occurring after biologic therapy withdrawal in plaque psoriasis, detailing clinical characteristics and independent risk factors to guide vigilant monitoring and
This review synthesizes current evidence on ruxolitinib 1.5% cream efficacy and safety in cutaneous lichen planus, highlighting significant lesion and pruritus reduction in a pivotal phase 2 RCT, supporting its potential as a novel topical
This study reveals that 30.7% of atopic dermatitis patients treated with dupilumab develop ocular surface disease, despite prevalent ocular symptoms at baseline and increased ophthalmic treatment during therapy, linked to reduced conjunctiv
Cherry angiomas are significantly more prevalent and occur at younger ages in individuals with Neurofibromatosis Type 1 (NF1), linked to biallelic NF1 inactivation in vascular cells. This discovery expands the vascular phenotype of NF1 and
Brepocitinib, a selective TYK2-JAK1 inhibitor, showed rapid, sustained skin disease control, itch relief, and improved quality of life in dermatomyositis patients over 52 weeks with an acceptable safety profile in a global phase 3 trial.
We present a molecularly confirmed case of CHILD syndrome mimicking Hailey-Hailey disease without classical features, highlighting diagnostic pitfalls and benefits of targeted therapy.
Elevated serum amyloid A correlates with rapidly progressive interstitial lung disease and mortality in dermatomyositis, with combined assessment alongside anti-MDA5 antibody improving risk stratification.
Intraoperative isolation of autologous epidermal stem cells using Myseed technology improves vascularization, survival, and contraction rates of single-stage composite skin grafts in full-thickness wounds, offering a promising approach for
A randomized clinical trial shows online team-based care is as effective as conventional in-person treatment for atopic dermatitis, offering an accessible alternative for chronic disease management.
