Background and Disease Burden
Chronic kidney disease (CKD) is a prevalent condition globally, affecting millions and substantially increasing the risk of cardiovascular complications, notably heart failure (HF). HF presents a major clinical burden with high morbidity and mortality rates. Understanding the pathogenic links between CKD and incident HF remains a critical unmet need. Circulating plasma proteins, as functional effectors and biomarkers, offer a window into molecular pathways that may contribute to HF development in CKD populations. Advanced proteomic technologies now enable comprehensive screening of plasma proteins to uncover novel mechanistic insights and potential clinical targets.
