Unraveling Molecular Links Between Chronic Kidney Disease and Heart Failure via the Plasma Proteome
Background and Disease Burden
Chronic kidney disease (CKD) is a prevalent condition globally, affecting millions and substantially increasing the risk of cardiovascular complications, notably heart failure (HF). HF presents a major clinical burden with high morbidity and mortality rates. Understanding the pathogenic links between CKD and incident HF remains a critical unmet need. Circulating plasma proteins, as functional effectors and biomarkers, offer a window into molecular pathways that may contribute to HF development in CKD populations. Advanced proteomic technologies now enable comprehensive screening of plasma proteins to uncover novel mechanistic insights and potential clinical targets.
Study Design
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.