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Optimizing Colorectal Cancer Screening Outreach for Adults Aged 45-49: Insights From a Large-Scale Randomized Trial

MedXY Editorial Team•Oct 7, 2025•Clinical Updates
colonoscopycolorectal cancer screeningpopulation healthrandomized clinical trial

Highlight

1. In a randomized trial involving 20,509 adults aged 45 to 49 years, usual care with mailed fecal immunochemical test (FIT) outreach led to a significantly higher screening participation (26.2%) compared to three active choice strategies (14.5% to 17.4%).

2. Offering a dual-modality active choice between FIT or colonoscopy modestly improved screening completion compared to a single active choice intervention.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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