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This review synthesizes clinical trial evidence showing that PPARγ and GLP1 receptor agonists modulate brain insulin signaling biomarkers in neuropsychiatric and neurodegenerative disorders, revealing CNS-specific metabolic effects beyond p
A comprehensive European cohort study reveals that Helicobacter pylori infection’s association with insulin resistance is confounded by socioeconomic and lifestyle factors, arguing against its independent causal role and the need for
This study reveals a high heart failure risk within 5 years of diabetes diagnosis, highlighting insulin resistance and reduced kidney function as independent predictors beyond conventional risk factors.
Elevated endogenous insulin and insulin resistance independently predict progression of diastolic dysfunction and increased cardiovascular mortality, highlighting early metabolic dysregulation as a target to prevent heart failure with prese
In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.
Higher insulin resistance before pregnancy was linked to poorer ovulation, lower pregnancy and live-birth rates, and more gestational diabetes in women with PCOS. Improving insulin resistance during treatment was associated with better preg
Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.
CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.
New research reveals accelerated glucose absorption in early MASLD patients, independent of gastric emptying. This metabolic alteration may drive liver disease progression before hepatic insulin resistance develops.
Stable-isotope OGTT data suggest that early MASLD is linked to higher oral glucose absorption, independent of gastric emptying, with preserved hepatic insulin suppression but impaired peripheral glucose clearance.
A multicenter retrospective cohort study reveals that metabolic bariatric surgery in 162 adults with type 1 diabetes and obesity achieved 29.7% weight loss at one year, reduced insulin requirements by 57%, and significantly improved glycemi
A comprehensive study combining the German Diabetes Study data and Mendelian randomization establishes a causal link between insulin resistance and reduced lung function (FEV1 and FVC), positioning the lung as a critical target for metaboli
A longitudinal study of 2,260 participants confirms that oral glucose tolerance test (OGTT)-based surrogate indexes, particularly Gutt and Cederholm, are superior to fasting-only measures in predicting type 2 diabetes, providing high clinic
Obesity-induced insulin resistance hinders heart failure recovery post-LVAD by disrupting the pentose phosphate pathway. A new study in Circulation suggests insulin sensitizers could restore cardiac repair mechanisms in obese patients.
Evidence from the Myovasc study reveals that insulin resistance and C-peptide levels are independent predictors of impaired cardiac vagal activity in heart failure, suggesting that metabolic health directly influences autonomic regulation b
The Myovasc study demonstrates that insulin resistance and secretion markers, rather than glucose levels alone, are independently associated with impaired cardiac vagal activity in heart failure patients, suggesting a metabolic-autonomic ax
A post hoc analysis of the CHANCE-2 trial suggests that the clinical benefit of ticagrelor over clopidogrel for secondary stroke prevention in CYP2C19 loss-of-function carriers is significantly attenuated in patients with high insulin resis
A 2025 meta-analysis of 19 RCTs (n=1657) found liraglutide combined with metformin improved glycaemia, insulin resistance, BMI, sex hormones and lipids versus metformin alone in overweight or obese women with PCOS; evidence certainty was lo
A 2025 meta-analysis of 19 RCTs (n=1657) found liraglutide combined with metformin improved glycaemia, insulin resistance, BMI, sex hormones and lipids versus metformin alone in overweight or obese women with PCOS; evidence certainty was lo
This study demonstrates that the triglyceride glucose-waist height ratio (TyG-WHtR) index independently predicts cardiometabolic multimorbidity risk in Chinese adults aged ≥45, showing a linear dose-response relationship and improved predic
