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This longitudinal cohort study reveals year-specific bidirectional associations between problematic social media use and depressive symptoms in adolescents, with stronger effects in females, while no prospective links were found for anxiety
Loneliness in individuals with traumatic spinal cord injury correlates strongly with environmental barriers and depressive symptoms, highlighting the interplay of internal and external factors in mental health outcomes.
Anxiety and depression negatively influence satisfaction and revision rates after functional septorhinoplasty but do not affect outcomes following aesthetic septorhinoplasty.
This article reviews a large retrospective study revealing significant associations between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure, highlighting the potential for genotype-guided personalized antidepressant therapy.
Functional rhinoplasty improves nasal obstruction symptoms and these disease-specific improvements correlate with reductions in anxiety, depression, and pain/discomfort, influencing long-term global quality of life.
This article reviews the complex interplay between major depressive disorder during pregnancy and selective serotonin reuptake inhibitor treatment, highlighting the importance of prioritizing maternal mental health to optimize outcomes for
This review synthesizes evidence linking smartphone acquisition and use at age 13 to depression, obesity, and sleep insufficiency at age 14, highlighting that use intensity rather than mere acquisition mediates health risks, with behavioral
A large-scale study identifies key active components of psychosocial interventions delivered by non-specialists, revealing social support, behavioral activation, and problem management as most effective for treating common mental disorders,
This randomized trial compared connectivity-based versus scalp-based targeting of accelerated TMS in treatment-resistant depression, showing greater antidepressant effects with individualized connectivity-guided targeting.
This review synthesizes randomized trial evidence demonstrating that intermittent theta burst stimulation (iTBS) targeting the dorsomedial PFC modulates default mode network activity, enhancing expectancy-driven placebo mood responses in de
A randomized trial found that an 8-week digital mindfulness app improved anxiety, depression, and stress in adults with non-infectious uveitis, but did not significantly change vision-related quality of life.
Magnetic seizure therapy was non-inferior to right unilateral ultra-brief ECT for depression remission and caused less autobiographical memory worsening, suggesting a promising convulsive treatment option with better cognitive safety.
A small randomized trial found that blocking IL-6 with tocilizumab showed promising, clinically meaningful trends for inflammation-related, hard-to-treat depression, especially for somatic symptoms, fatigue, anxiety, and quality of life, th
A landmark Swedish cohort study of 95,490 patients reveals that semaglutide is associated with a 42% lower risk of worsening mental illness in people with depression and anxiety, while other GLP-1 receptor agonists show varied effects. The
A large-scale Korean cohort study reveals thyroid cancer survivors face a significantly higher risk of depression in the first five years post-diagnosis, independent of treatment modality or hormone dosage.
This review analyzes the high prevalence of anxiety and depression in patients with Retrograde Cricopharyngeus Dysfunction (RCPD) and evaluates the significant, sustained mental health improvements following cricopharyngeal botulinum toxin
A systematic review and meta-analysis of 12 clinical trials reveals that the quantity of preparation therapy—not post-dose integration—significantly predicts depressive symptom reduction in psychedelic-assisted therapy, highlighting the cri
This population-based cohort study highlights how cumulative psychosocial stress across the life course significantly escalates the risk of neurovascular and neurodegenerative diseases, identifying depression as a critical target for interv
A large-scale randomized controlled trial reveals that online self-help programs, featuring either automated or individualized psychological support, significantly reduce the mental health burden on informal caregivers of people with depres
The CLARO randomized clinical trial investigated whether a collaborative care model could improve outcomes for patients with opioid use disorder and co-occurring depression or PTSD. The study found no statistically significant advantages ov
