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A nationwide observational study reveals tocilizumab use in giant cell arteritis significantly lowers major adverse cardiovascular events compared to methotrexate, highlighting its potential cardiovascular benefits beyond inflammation contr
Lepodisiran, an siRNA targeting Lp(a), significantly reduces oxidized phospholipids on apo(a) and apoB, highlighting its therapeutic potential in lowering cardiovascular risk linked to elevated Lp(a).
The VRONI study demonstrates the feasibility and effectiveness of combined biochemical and genetic screening for familial hypercholesterolaemia (FH) in children, revealing a higher FH prevalence than previously reported and supporting natio
A randomized clinical trial demonstrates that routine cardiovascular specialist referral for prostate cancer patients improves cholesterol control but does not reduce major cardiovascular events over nearly 6 years.
Elevated lipoprotein(a) confers a consistent relative risk increase for atherosclerotic cardiovascular disease across all adult ages, with absolute risks rising substantially in older adults.
Evolocumab significantly reduces first and subsequent major adverse cardiovascular events in high-risk patients without prior myocardial infarction or stroke, affirming the benefit of intensive LDL-C lowering for cumulative cardiovascular r
Long-term data from lung cancer screening reveal centrilobular emphysema progression strongly associates with coronary artery calcification worsening, highlighting systemic vascular implications of this emphysema subtype.
This population-wide study demonstrates that parathyroidectomy in primary hyperparathyroidism reduces major adverse cardiovascular events risk, particularly in patients with higher serum calcium levels.
Early weight loss after impaired glucose tolerance diagnosis is linked to markedly reduced long-term risk of cardiovascular events and death, underscoring the importance of early lifestyle interventions in prediabetes management.
This meta-analysis of 17 Phase 3 RCTs reveals that BTK inhibitors, primarily ibrutinib, increase the risk of non-fatal ischemic cardiovascular events in patients with B-cell malignancies, highlighting important safety considerations.
Achieving a ≥50% reduction in LDL-C from baseline independently reduces recurrent cardiovascular events post-ischemic stroke, suggesting that combining relative and absolute LDL-C targets improves long-term outcomes.
This analysis reveals that waist circumference and waist-to-hip ratio improve cardiovascular risk classification beyond BMI, identifying individuals with hidden risk and refining prognostic assessments across multiple cardiovascular outcome
A race-free adaptation of the MESA risk score estimates 10-year coronary heart disease risk with comparable accuracy to the original, challenging the necessity of including race/ethnicity in cardiovascular risk prediction.
The VasCog-2-WSO criteria effectively detect MRI-defined vascular cognitive impairment in asymptomatic adults, correlating with increased cardiovascular risk and mortality, highlighting their utility for early diagnosis and community risk s
A study of 305 individuals with type 2 diabetes found that blood-based DNA methylation models predicted 5-year major adverse cardiovascular events with high accuracy, suggesting potential for improved risk stratification.
This analysis of the SOUL trial shows oral semaglutide reduces major cardiovascular events, with greater benefits linked to higher baseline HbA1c and larger HbA1c reductions, while BMI changes did not significantly affect outcomes.
This study introduces and validates a simplified machine learning-based equation for estimating LDL cholesterol, showing comparable accuracy to the original Martin-Hopkins method and improved ease of use.
This study compares the predictive value of non-HDL cholesterol and apolipoprotein B for atherosclerotic cardiovascular disease risk in individuals not on lipid-lowering medication.
This study reveals that specific gene mutations and cardiovascular risk factors significantly influence prognosis and thrombotic risk in triple-negative essential thrombocythemia, highlighting the importance of molecular profiling for perso
This study from two Spanish cohorts explores how moderate wine consumption within a Mediterranean diet impacts cardiovascular disease and mortality, suggesting modest benefits but advising cautious interpretation.
