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Longitudinal tau-PET accumulation follows distinct regional patterns across biological AD stages; aligning trial inclusion and outcome ROIs to baseline tau stage can substantially reduce sample sizes and improve power for disease-modifying
A secondary analysis of TRAILBLAZER‑ALZ 2 found that lower posttreatment amyloid plaque levels after donanemab correlate strongly with less clinical decline and reductions in plasma p‑tau217, p‑tau181, and GFAP over 76 weeks, supporting pla
Elevated VCAM-1 levels correlate with worse outcomes in chronic HFrEF, independent of conventional markers; dapagliflozin’s benefits are consistent across VCAM-1 levels, highlighting inflammatory pathways as therapeutic targets.
A multicentre prospective nested case‑control analysis (REPO2MSE) identifies extratemporal seizure onset, BMI ≥30, male sex, and predominantly nocturnal seizures as independent SUDEP risk factors in drug‑resistant focal epilepsy; peri‑ictal
Elevated high-sensitivity cardiac troponin I and T levels, indicative of subclinical myocardial injury in midlife, are associated with accelerated cognitive decline, structural brain changes, and increased dementia risk in later life.
In BigpAK-2, a multinational randomized trial, a KDIGO-based preventive bundle triggered by tubular stress biomarkers reduced moderate or severe acute kidney injury within 72 hours after major surgery (OR 0.57; NNT 12) without increasing ad
A randomized, double‑blind crossover trial in healthy volunteers found lacosamide acutely reduced strength–duration time constant and other excitability metrics in large myelinated peripheral fibers; pregabalin and tapentadol produced no co
In a large prospective cohort, obese BMI (≥30) was associated with worse post-concussion neurocognitive outcomes and a persistently proinflammatory blood biomarker profile, despite fewer baseline symptoms. Findings suggest obesity modifies
This study identifies reduced neural efficiency during threat processing as a biomarker in pediatric anxiety disorders, linked to diagnosis and poorer CBT outcomes, offering potential for patient stratification and novel intervention target
This study explores how biological sex influences CRS diagnosis and inflammatory biomarkers, revealing sex-specific patterns that could inform personalized treatment.
This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.
A 30-year birth cohort study reveals that life-course factors, especially modifiable markers like BMI, blood glucose, and blood pressure, significantly influence the buildup of chronic diseases across eight organ systems, yet much remains u
Enlarged perivascular spaces (EPVS) correlate with serum biomarkers of neuroinflammation and amyloid pathology and associate with cognitive impairment, supporting their role as early MRI markers for Alzheimer disease (AD) vascular contribut
A response-adapted trial of daratumumab monotherapy in elderly newly diagnosed multiple myeloma reveals key biomarkers—CD38 expression, plasma cell phenotype, and immune microenvironment—that predict treatment sensitivity and inform therape
Recent advances in anti-β amyloid monoclonal antibodies offer promising reductions in Alzheimer’s disease progression but spark debate regarding their clinical impact, cost-effectiveness, and accessibility. Emerging biomarkers and preventiv
A phase 2b trial demonstrates that several noninvasive tests reliably reflect treatment response to semaglutide in patients with metabolic dysfunction-associated steatohepatitis, correlating with histologic improvements over 72 weeks.
A biomarker-based ABC-AF risk score-guided treatment did not improve stroke or death outcomes versus standard care in atrial fibrillation, underscoring the need for prospective validation of precision medicine tools before clinical implemen
Mental disorders currently diagnosed symptomatically can be redefined using biology-informed frameworks integrating biological, behavioral, and environmental data. The Precision Psychiatry Roadmap aims to harmonize global research and clini
This study establishes reliable FeNO reference values throughout life in respiratory healthy individuals, highlighting factors that influence nitric oxide levels and enhancing asthma diagnosis and management.
A comprehensive proteomic analysis from the ARIC study identifies plasma proteins linking kidney dysfunction to incident heart failure, highlighting potential biomarkers and therapeutic targets for HF prevention in CKD patients.
