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Internal Medicine

Unraveling the Hidden and Measured Drivers of Chronic Disease Accumulation Across Organ Systems

MedXY Editorial TeamOct 20, 2025
biomarkerschronic diseaseepidemiologymultimorbidity

Highlight

  • Measured and unmeasured life-course factors explain 24.5-86.3% of chronic disease accumulation across eight major organ systems.
  • Unmeasured factors contribute substantially, accounting for most variance in chronic disease burden.
  • Key modifiable measured drivers include body mass index (BMI), fasting blood glucose, and systolic blood pressure.
  • The findings underscore the complexity of multimorbidity and the need for further research on hidden determinants.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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