Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies
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– Individuals with peripartum cardiomyopathy (PPCM), alcohol-induced cardiomyopathy (ACM), and cancer therapy–related cardiomyopathy (CCM) show enrichment for both rare monogenic DCM variants and a high polygenic risk score for DCM.
– In multi-cohort analyses (Mass General Brigham Biobank with replication in UK Biobank, FinnGen, and the VA Million Veteran Program), a 1-SD higher DCM polygenic score was associated with adjusted odds ratios of ~1.6–1.8 for secondary cardiomyopathies; high polygenic scores conferred roughly 3-fold increased odds in medical-record reviewed cases.
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.