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MedXY AI/MedXY News/Tag: polygenic risk
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Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity
GastroenterologyCrohn’s diseasedisease severity

Genetic Risk of Inflammatory Bowel Disease Linked to Disease Severity

By MedXY|May 1, 2026

A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn’s and ulcerative coli

Genetic Liability for Suicide Attempt Is Linked to Aggression and Environmental Stressors: New Insights into Polygenic Risk
newspolygenic riskpsychiatry

Genetic Liability for Suicide Attempt Is Linked to Aggression and Environmental Stressors: New Insights into Polygenic Risk

By MedXY|Feb 12, 2026

A landmark case-control study identifies significant associations between polygenic risk scores for suicide attempts and specific clinical traits, including aggression and depression severity, while also highlighting the interplay between g

Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies
Cardiologycardiomyopathygenetics

Shared Genetic Vulnerability: Polygenic and Monogenic Contributions to Peripartum, Alcohol-Induced, and Cancer Therapy–Related Cardiomyopathies

By MedXY|Dec 3, 2025

A large multi-cohort genetic analysis shows that both rare monogenic variants and a high polygenic score for dilated cardiomyopathy (DCM) are enriched in peripartum, alcohol-induced, and cancer therapy–related cardiomyopathies, supporting a

Common, Rare and Somatic Genetic Drivers Together Double 5‑Year Atrial Fibrillation Risk: Toward an Integrated Genomic Model (IGM‑AF)
Cardiologyatrial fibrillationClonal hematopoiesis

Common, Rare and Somatic Genetic Drivers Together Double 5‑Year Atrial Fibrillation Risk: Toward an Integrated Genomic Model (IGM‑AF)

By MedXY|Dec 3, 2025

A UK Biobank whole‑genome study finds polygenic, rare monogenic, and somatic (CHIP) variants each independently associate with incident atrial fibrillation (AF); combined genomic profiling plus clinical risk (CHARGE‑AF) improves discriminat

Genetic Liability to Hypertensive Disorders of Pregnancy Predicts Increased Long‑Term Cardiovascular Risk: Mendelian Randomization and Polygenic Risk Evidence
Cardiologycardiovascular riskgestational hypertension

Genetic Liability to Hypertensive Disorders of Pregnancy Predicts Increased Long‑Term Cardiovascular Risk: Mendelian Randomization and Polygenic Risk Evidence

By MedXY|Nov 28, 2025

Genetic predisposition to preeclampsia and gestational hypertension is associated with higher risk of later-life cardiovascular disease; polygenic risk amplifies this risk, while obstetric history improves risk stratification beyond PRSs al

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