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A Danish nationwide study reveals higher genetic risk scores for IBD predict more severe disease courses, including increased surgery rates, stronger medication needs, and worse inflammatory markers in both Crohn’s and ulcerative coli
A landmark case-control study identifies significant associations between polygenic risk scores for suicide attempts and specific clinical traits, including aggression and depression severity, while also highlighting the interplay between g
A large multi-cohort genetic analysis shows that both rare monogenic variants and a high polygenic score for dilated cardiomyopathy (DCM) are enriched in peripartum, alcohol-induced, and cancer therapy–related cardiomyopathies, supporting a
A UK Biobank whole‑genome study finds polygenic, rare monogenic, and somatic (CHIP) variants each independently associate with incident atrial fibrillation (AF); combined genomic profiling plus clinical risk (CHARGE‑AF) improves discriminat
Genetic predisposition to preeclampsia and gestational hypertension is associated with higher risk of later-life cardiovascular disease; polygenic risk amplifies this risk, while obstetric history improves risk stratification beyond PRSs al
