Septic Shock in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: Outcomes, Prognostic Factors, and Clinical Implications from a Multicenter ICU Cohort

Highlight

• Septic shock is a leading cause of ICU admission among allo-HSCT recipients, with a 63% mortality at 90 days.
• Higher SOFA scores, fungal infections, and neutropenia independently predict poorer 90-day survival after septic shock.
• Early aminoglycoside therapy correlates with improved short-term survival, though its causal role remains uncertain.
• Age, graft-versus-host disease type, and early bacterial documentation do not independently affect 90-day mortality.

Study Background and Disease Burden