Paracetamol Lowers Cerebral Temperature Modestly but Meaningfully in Febrile Brain‑Injured Patients: Results of the NEUROTHERM Randomized Pharmacodynamic Trial
– A single intravenous dose of paracetamol reduced mean cerebral temperature (CT) by 0.6°C versus placebo over 6 hours in febrile brain‑injured patients (n = 99).
– Paracetamol maintained CT <38.5°C for a median 215 minutes vs. 0 minutes with placebo; however, ~30% of treated patients were nonresponders.
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