Critical Carefeverneurocritical care
Paracetamol Lowers Cerebral Temperature in Febrile Brain‑Injured Patients — NEUROTHERM RCT Shows a Modest, Clinically Relevant Effect
By MedXY|Dec 10, 2025
In the NEUROTHERM randomized pharmacodynamic trial, a single IV dose of paracetamol reduced intracerebral temperature by a mean 0.6°C in febrile brain‑injured patients and kept temperatures <38.5°C for a median 3.6 hours versus virtually
