Adults with congenital heart disease (ACHD) and matched controls had similar 1-year mortality and recurrent acute myocardial infarction (AMI) rates after a first AMI.
Before matching, ACHD patients were younger than controls at the time of first AMI (mean age 58 vs 70 years).
A higher 10-year mortality rate in the ACHD group (hazard ratio 1.4, 95% CI 1.0-1.9) did not persist after adjustment.
The authors call for healthy lifestyles and proactive management of traditional cardiovascular risk factors in ACHD patients.
Study Snapshot
Design | Nationwide case-control study |
|---|---|
Study period | 2000-2022 |
Population | Adults with ACHD and controls who experienced a first acute myocardial infarction; 214 ACHD patients and 275,377 controls identified, with 213 ACHD patients matched to 2,092 controls |
Matching factors | Age, sex, hypertension, diabetes, hyperlipidaemia, and history of percutaneous coronary intervention or coronary artery bypass grafting |
Follow-up | Mean 6.5 years for ACHD patients and 7.3 years for controls |
Primary outcomes | All-cause mortality and recurrent acute myocardial infarction |
Main results | No significant difference in 1-year mortality or recurrent AMI; 10-year mortality HR 1.4 (95% CI 1.0-1.9), no longer significant after adjustment |
Limitations | Observational design; residual confounding possible; abstract-level data |
