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SMOC-1, secreted by cardiomyocytes after acute myocardial infarction, supports fibrosis and scar formation, reducing cardiac rupture risk. Enhancing this pathway offers promising therapeutic potential.
In a nationwide case-control study, adults with congenital heart disease had similar 1-year mortality and recurrent heart attack rates after a first acute myocardial infarction as matched controls. A higher 10-year mortality estimate did not persist after adjustment, supporting aggressive cardiovascular risk-factor management.
In patients with acute myocardial infarction, silent plaque rupture was found in 12% of non-obstructive lesions in non-infarct-related arteries. Larger plaques, positive remodeling, and thinner fibrous caps were linked to rupture, and more
A MINT trial subanalysis found no evidence that ICU status changes the relative effect of restrictive versus liberal transfusion in acute myocardial infarction with anemia.
A landmark multimodality imaging study reveals that silent plaque ruptures occur in 12% of non-obstructive lesions in AMI patients. Over 50% of these ruptures heal within a year, highlighting the dynamic nature of coronary atherosclerosis a
A clinical study demonstrates that catheter ablation is a highly effective rescue therapy for refractory, scar-related ventricular tachycardia occurring in the early phase of acute myocardial infarction, challenging traditional management t
In low‑risk AMI patients with early complete revascularization and uneventful 1‑month DAPT, P2Y12‑inhibitor monotherapy was noninferior to continued DAPT for ischemic outcomes and substantially reduced clinically relevant bleeding.
In low‑risk acute MI patients with early complete revascularization and 1 month of uneventful DAPT, stopping aspirin and continuing P2Y12‑inhibitor monotherapy was noninferior for ischemic outcomes and cut clinically relevant bleeding nearl
A large population study shows frailty is independently linked to worse 1‑year outcomes after AMI across ages, with the largest relative impact in patients under 55 — underscoring the need to assess frailty beyond geriatric populations.
An updated meta-analysis evaluates the effects of 0.5 mg colchicine on clinical outcomes after acute myocardial infarction, showing reduced hospital readmission but increased diarrhea risk without significant impact on major cardiovascular
This prespecified analysis of the MINT trial evaluates how liberal versus restrictive red blood cell transfusion strategies affect 30-day outcomes in acute MI patients, focusing on those undergoing revascularization, revealing nuanced risk
A novel clinical classification incorporating cardiac imaging refines diagnosis of acute myocardial infarction, distinguishing spontaneous, secondary, and non-infarction cases, improving risk stratification and guiding targeted treatment.
Elevated CRP levels independently predict short-term mortality in acute myocardial infarction complicated by cardiogenic shock, with extracorporeal life support showing no survival benefit regardless of CRP levels or admission timing.
