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Combined intrahepatic and periduodenal lymphatic embolization significantly improves protein balance and remission duration in congenital heart disease patients with protein-losing enteropathy compared to intrahepatic embolization alone, of
This article explores the high prevalence of heart failure with preserved ejection fraction (HFpEF) in adults with congenital heart disease (ACHD), highlighting its clinical features, hospitalization burden, and under-treatment issues.
In a nationwide case-control study, adults with congenital heart disease had similar 1-year mortality and recurrent heart attack rates after a first acute myocardial infarction as matched controls. A higher 10-year mortality estimate did not persist after adjustment, supporting aggressive cardiovascular risk-factor management.
Latent class analysis of 889 adult PAH-CHD patients identified unique phenogroups with distinct survival outcomes and treatment responses, offering refined risk stratification and guiding personalized therapy.
A Circulation study identifies MAML1 as a candidate congenital heart disease gene and shows that defective phase separation in endocardial cells suppresses Notch signaling, impairing endocardial-to-mesenchymal transition and causing septal
The CORECA study reveals that preprocedural 3D anatomic and substrate reconstruction from CT or MRI effectively identifies ventricular tachycardia targets in complex congenital heart disease, achieving 87.5% concordance with electroanatomic
A comprehensive study highlights that over half of publicly insured children develop neurodevelopmental disorders within five years of infant cardiac surgery. While service utilization is high, a critical gap persists between initial screen
A multicenter trial confirms the Minima Stent’s efficacy in treating pulmonary artery stenosis and aortic coarctation in infants. With a 97.6% success rate and growth-accommodating design, it addresses a critical unmet need in pediatr
A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a gen
This study identifies key Fontan circulatory failure morbidities impacting survival from heart transplant waitlisting through one year post-transplant, highlighting cyanosis and frequent hospitalizations as critical risk factors.