The increasing prevalence of cardiometabolic (CM) diseases, which include conditions such as obesity, diabetes, and cardiovascular disease, raises significant public health concerns. These diseases are often associated with chronic low-grade inflammation, a process that can be influenced by various factors, most notably alterations in gut microbiota (GM) and compromised intestinal barrier integrity. The SINFONI project emerged to investigate a multifunctional (MF) nutritional strategy aimed at modulating inflammation and GM composition through the inclusion of diverse bioactive compounds in the diet.
Study Overview
In this randomized crossover-controlled study, 30 individuals identified as being at risk for cardiometabolic diseases participated in a dietary intervention over a period of 2 months. Participants consumed MF cereal products enriched with key bioactive components such as polyphenols, fibers, slowly digestible starch, and omega-3 fatty acids. In contrast, a control group consumed cereal products without any bioactive compounds.
