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Genetic Influences on Macronutrient Preferences and Their Impact on Childhood Food Intake and Metabolic Health
Diabetes & EndocrinologyHypothalamusMacronutrient intake

Genetic Influences on Macronutrient Preferences and Their Impact on Childhood Food Intake and Metabolic Health

By MedXY|Sep 12, 2026

This cohort study links polygenic scores for macronutrient intake with specific food choices in children and adolescents, highlighting genetic pathways involving hypothalamic appetite regulation but limited effects on cardiometabolic outcom

Genetic Insights into Childhood Blood Pressure and Heart Rate: Implications for Adult Cardiometabolic Health
Cardiologygenetic determinants
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childhood blood pressure

Genetic Insights into Childhood Blood Pressure and Heart Rate: Implications for Adult Cardiometabolic Health

By MedXY|Sep 5, 2026

Large-scale GWAS highlight novel genetic loci influencing childhood blood pressure and heart rate, with polygenic risk scores predicting adult cardiometabolic outcomes, underscoring the importance of early-life genetic determinants in cardi

Gut Microbiota-Derived Imidazole Propionate as a Predictor of Cardiometabolic Risk in Coronary Artery Disease: Evidence and Clinical Implications
Cardiologycoronary artery diseasegut microbiota

Gut Microbiota-Derived Imidazole Propionate as a Predictor of Cardiometabolic Risk in Coronary Artery Disease: Evidence and Clinical Implications

By MedXY|Aug 18, 2026

Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into pe

Longitudinal Changes in Cortisol Secretion and Cardiometabolic Outcomes in Benign Adrenal Incidentalomas: Insights from a Large Retrospective Cohort
Diabetes & Endocrinologyadrenal incidentalomacardiometabolic risk

Longitudinal Changes in Cortisol Secretion and Cardiometabolic Outcomes in Benign Adrenal Incidentalomas: Insights from a Large Retrospective Cohort

By MedXY|Jul 10, 2026

This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype

Impact of Chronic Mild Sleep Restriction on Body Weight and Composition: Insights from Pooled Randomized Trials
Diabetes & EndocrinologyAdipositybody weight

Impact of Chronic Mild Sleep Restriction on Body Weight and Composition: Insights from Pooled Randomized Trials

By MedXY|Jul 9, 2026

Prolonged mild sleep restriction of 1.5 hours per night over six weeks leads to modest weight gain, increased adiposity, and elevated leptin levels, highlighting the importance of adequate sleep in weight management and cardiometabolic risk

Younger Adults With Type 2 Diabetes Show a More Adverse Cardiometabolic Profile Than Older Adults
Cardiologyage-related patternscardiometabolic risk

Younger Adults With Type 2 Diabetes Show a More Adverse Cardiometabolic Profile Than Older Adults

By MedXY|May 28, 2026

Across four national cohorts, younger adults with type 2 diabetes had higher adiposity and triglycerides, while glycemia peaked in midlife and blood pressure and albuminuria rose with age, suggesting age-specific pathways to diabetes compli

Adolescent MASLD Plus PCOS Signals a Higher-Risk Cardiometabolic Trajectory Into Adulthood
Diabetes & Endocrinologycardiometabolic riskinsulin resistance

Adolescent MASLD Plus PCOS Signals a Higher-Risk Cardiometabolic Trajectory Into Adulthood

By MedXY|May 28, 2026

In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.

Semaglutide Mitigates Cardiometabolic Risk in Early-Stage Schizophrenia: Insights from a Randomized Clinical Trial
Diabetes & Endocrinologycardiometabolic riskGLP-1 receptor agonists

Semaglutide Mitigates Cardiometabolic Risk in Early-Stage Schizophrenia: Insights from a Randomized Clinical Trial

By MedXY|Feb 11, 2026

A landmark RCT demonstrates that adjunctive semaglutide significantly improves glycemic control and induces substantial weight loss in individuals with schizophrenia spectrum disorders treated with second-generation antipsychotics, potentia

Tirzepatide Lowers 10‑Year Predicted Risk of Cardiovascular Disease and Type 2 Diabetes in Adults with Obesity and Prediabetes: Post hoc Analysis of SURMOUNT‑1
Cardiologycardiometabolic riskobesity

Tirzepatide Lowers 10‑Year Predicted Risk of Cardiovascular Disease and Type 2 Diabetes in Adults with Obesity and Prediabetes: Post hoc Analysis of SURMOUNT‑1

By MedXY|Dec 5, 2025

A post hoc analysis of the three‑year SURMOUNT‑1 trial found that once‑weekly tirzepatide (5–15 mg) produced dose‑dependent reductions in 10‑year predicted risks for ASCVD, heart failure, total CVD and progression to type 2 diabetes versus

Not All Antidepressants Are the Same: Differential Cardiometabolic and Physiological Effects from a Large Network Meta‑analysis
Cardiologyantidepressantscardiometabolic risk

Not All Antidepressants Are the Same: Differential Cardiometabolic and Physiological Effects from a Large Network Meta‑analysis

By MedXY|Nov 10, 2025

A 151‑trial network meta‑analysis of 58,534 participants shows marked differences among 30 antidepressants in weight, blood pressure, heart rate, lipids, glucose and liver enzymes; findings support individualized choice and targeted baselin

Trends in Body Composition and Cardiometabolic Risk Factors in Spanish Children Over Three Decades
Cardiologybody compositioncardiometabolic risk

Trends in Body Composition and Cardiometabolic Risk Factors in Spanish Children Over Three Decades

By MedXY|Oct 6, 2025

This article reviews a 30-year study from Spain analyzing body composition and cardiometabolic risk factors in children aged 8-11, showing obesity plateauing, lipid improvements, blood pressure reductions, but rising insulin levels from 199

Multifunctional Dietary Approach to Reduce Intestinal Inflammation in Cardiometabolic Risk Subjects: Insights from the SINFONI Project
Cardiologycardiometabolic riskgut microbiota

Multifunctional Dietary Approach to Reduce Intestinal Inflammation in Cardiometabolic Risk Subjects: Insights from the SINFONI Project

By MedXY|Oct 2, 2025

This article explores how a multifunctional dietary strategy can alleviate intestinal inflammation linked to cardiometabolic risk by modifying gut microbiota composition.

Preterm Birth Linked to Long-Term Adult Cardiometabolic and Mental Health Risks: New U.S. Cohort Study
Cardiologycardiometabolic riskmental health

Preterm Birth Linked to Long-Term Adult Cardiometabolic and Mental Health Risks: New U.S. Cohort Study

By MedXY|Sep 30, 2025

Adults born preterm face significantly higher risks of cardiometabolic abnormalities and internalizing mental health problems by age 35, according to a new U.S. cohort study.

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