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This study finds that waist circumference is a better and more practical tool than traditional cardiometabolic indices for detecting hypogonadism in men with Klinefelter Syndrome, enhancing clinical assessment beyond age alone.
This article explores recent meta-analytic evidence on how device-measured physical activity and sedentary behavior relate to cardiometabolic risk markers in children and adolescents, revealing nuanced benefits of moderate-to-vigorous exerc
Functional hypothalamic amenorrhea (FHA) in mid-adulthood is linked to increased coronary heart disease risk and type 2 diabetes, independent of traditional factors, highlighting menstrual irregularities as early cardiometabolic risk indica
Higher whole-grain intake consistently improves multiple cardiometabolic risk factors, with optimal benefits at 60–100 g/day. Evidence highlights reductions in adiposity, blood lipids, inflammation, glucose, and blood pressure, supporting w
This meta-analysis of 87 randomized trials finds that increasing whole-grain intake is associated with improved cardiometabolic risk factors including reduced body weight, cholesterol, and blood pressure, particularly at daily intakes of 60
This cohort study links polygenic scores for macronutrient intake with specific food choices in children and adolescents, highlighting genetic pathways involving hypothalamic appetite regulation but limited effects on cardiometabolic outcom
Large-scale GWAS highlight novel genetic loci influencing childhood blood pressure and heart rate, with polygenic risk scores predicting adult cardiometabolic outcomes, underscoring the importance of early-life genetic determinants in cardi
Emerging evidence identifies circulating imidazole propionate, a gut microbiota-derived metabolite, as an independent predictor of major adverse cardiovascular events in patients with coronary artery disease, offering novel insights into pe
This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype
Prolonged mild sleep restriction of 1.5 hours per night over six weeks leads to modest weight gain, increased adiposity, and elevated leptin levels, highlighting the importance of adequate sleep in weight management and cardiometabolic risk
Across four national cohorts, younger adults with type 2 diabetes had higher adiposity and triglycerides, while glycemia peaked in midlife and blood pressure and albuminuria rose with age, suggesting age-specific pathways to diabetes compli
In the Raine Study, adolescents with both MASLD and PCOS had a substantially worse cardiometabolic profile by age 27 than peers with either condition alone, highlighting a high-risk subgroup that may warrant earlier metabolic surveillance.
A landmark RCT demonstrates that adjunctive semaglutide significantly improves glycemic control and induces substantial weight loss in individuals with schizophrenia spectrum disorders treated with second-generation antipsychotics, potentia
A post hoc analysis of the three‑year SURMOUNT‑1 trial found that once‑weekly tirzepatide (5–15 mg) produced dose‑dependent reductions in 10‑year predicted risks for ASCVD, heart failure, total CVD and progression to type 2 diabetes versus
A 151‑trial network meta‑analysis of 58,534 participants shows marked differences among 30 antidepressants in weight, blood pressure, heart rate, lipids, glucose and liver enzymes; findings support individualized choice and targeted baselin
This article reviews a 30-year study from Spain analyzing body composition and cardiometabolic risk factors in children aged 8-11, showing obesity plateauing, lipid improvements, blood pressure reductions, but rising insulin levels from 199
This article explores how a multifunctional dietary strategy can alleviate intestinal inflammation linked to cardiometabolic risk by modifying gut microbiota composition.
Adults born preterm face significantly higher risks of cardiometabolic abnormalities and internalizing mental health problems by age 35, according to a new U.S. cohort study.
