Section
A landmark UK Biobank study demonstrates that elevated lipoprotein(a) independently predicts both the onset and progression of peripheral artery disease and carotid stenosis, beyond traditional cardiovascular risk factors.
A recent J Clin Oncol study shows that nearly 33% of RRMM patients treated with cilta-cel achieved ≥5 years of progression-free survival, highlighting durable responses and promising biomarkers.
A phase 2b trial found that efruxifermin did not significantly improve fibrosis at 36 weeks in patients with compensated cirrhosis due to MASH, though longer-term benefit was suggested at 96 weeks.
Mitochondrial donation by pronuclear transfer and preimplantation genetic testing effectively reduce transmission of pathogenic mtDNA variants, offering hope for families at risk of mitochondrial diseases.
MRD-guided consolidation strategies in transplant-eligible multiple myeloma patients did not significantly improve deep remission rates over conventional approaches, questioning the clinical utility of MRD-adapted intensification.
Lenacapavir (Yeztugo) becomes the first FDA-approved, twice-yearly injectable PrEP, offering robust long-acting HIV prevention and addressing key adherence barriers.
A large prospective cohort study links daily walking of over 100 minutes to reduced risk of chronic low back pain, emphasizing walking volume over intensity as a preventive strategy.
A twofold rise in advanced liver fibrosis among US heavy drinkers over two decades is linked to increased metabolic syndrome, age, and socioeconomic risk, not higher alcohol intake.
Recent findings of benzene in benzoyl peroxide acne products have sparked debate, recalls, and regulatory scrutiny, prompting calls for improved safety measures despite the continued clinical utility of these therapies.
A comprehensive Danish cohort study finds no evidence linking early childhood aluminum-adsorbed vaccines to increased risks of autoimmune, allergic, or neurodevelopmental disorders, supporting vaccine safety.
A randomized trial demonstrates that medial opening wedge high tibial osteotomy (HTO) slows cartilage loss and improves symptoms in patients with medial compartment knee osteoarthritis and varus alignment, supporting its role as a joint-pre
Over 60% of liver cancer cases are preventable, yet rising obesity and metabolic dysfunction threaten progress. The Lancet Commission outlines urgent strategies to curb a projected doubling of global liver cancer burden by 2050.
Adults born preterm face significantly higher risks of cardiometabolic abnormalities and internalizing mental health problems by age 35, according to a new U.S. cohort study.
A recent study reveals that most adults in US recreational states respond maladaptively to cannabis health warnings, highlighting challenges and opportunities for improved public health messaging.
The FDA has approved Sephience, an oral therapy for phenylketonuria (PKU), offering a novel treatment option for both children and adults with this rare metabolic disorder.
Recent studies confirm that both childhood and adult lead exposure, especially from gasoline and industrial sources, are associated with increased risk for cognitive decline and dementia in later life.
The CDC no longer universally recommends COVID-19 vaccination during pregnancy, prompting debate among clinicians as the FDA shifts vaccine composition to target the JN.1 variant. This article analyzes the evidence, rationale, and clinical
Norovirus vaccines show promise in clinical trials, but scientific and logistical challenges remain. No approved vaccine exists yet, though novel approaches, including oral pills, are advancing development.
A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention
Systemically biased AI models can reduce clinicians’ diagnostic accuracy, and explanations alone may not mitigate this harm, according to a multicenter study involving over 450 clinicians.
