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This multicenter retrospective study shows that GLP-1 receptor agonists improve glycemic control and cardiometabolic parameters with good tolerance in heart transplant recipients with type 2 diabetes, supporting their therapeutic role in th
This study explores myocardial external efficiency (MEE) and mitochondrial function in heart transplant recipients, revealing improved MEE at 6 months post-transplant associated with myocardial contractility and biomarkers, highlighting ene
HEARTBiT, a novel transcriptomic biomarker, effectively detects moderate-to-severe acute cellular rejection within the first year after heart transplantation, offering a minimally invasive alternative to biopsy, especially during the high-r
The SUSTAIN-IT study reveals variable improvements in health-related quality of life over two years following heart transplantation or long-term mechanical circulatory support in older heart failure patients, highlighting important consider
A multicenter study reveals that preserving donor hearts at 10°C results in better early graft function and one-year survival than traditional 4-8°C storage, suggesting a new standard for heart transplant preservation.
A machine-learning model using perioperative hemodynamic indices accurately predicted stage 2-3 acute kidney injury after orthotopic heart transplantation in 114 patients, with light gradient boosting machine achieving AUC 0.898.
The OPTN’s new status escalation policy for stable adult heart transplant candidates with durable LVADs may benefit only a small fraction of patients, as most experience complications or transplant within six years.
Recent heart-transplant studies show donor-derived cell-free DNA not only detects rejection but also predicts mortality and persistent graft dysfunction, especially when elevated at diagnosis. Evidence supports a shift from binary surveilla
In a prospective multicenter study, the EXCOR Active Driver demonstrated excellent reliability and high short-term survival in children requiring ventricular assist support, while supporting a registry-enabled pathway for class III pediatri
A prospective multicenter study found circulating microRNA rejection scores identified ACR and AMR with strong diagnostic performance and prognostic value, supporting their development as noninvasive tools to reduce reliance on surveillance
A large-scale analysis of 6,026 pediatric heart transplant candidates reveals that status exceptions often prioritize patients with lower mortality risk than those meeting standard criteria, highlighting a significant misalignment in the U.
A landmark study validates the first FFPE-based molecular diagnostic system for heart transplant rejection, demonstrating high accuracy in identifying antibody-mediated and cellular rejection through targeted gene expression profiling acros
A large-scale multicenter study reveals that while pre-transplant durable LVAD support increases the incidence of severe primary graft dysfunction (PGD), these patients paradoxically demonstrate significantly better survival rates compared
A longitudinal study of 944 heart transplant recipients reveals a staggering incidence of metabolic and renal dysfunction. While diabetes significantly increases mortality risk, the study highlights the potential of SGLT2 inhibitors and GLP
The CAVIAR trial reveals that while alirocumab significantly reduces LDL-C in heart transplant recipients, it does not arrest coronary plaque progression within the first year, suggesting that early cardiac allograft vasculopathy may be dri
