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Immune-related adverse events strongly predict early graft rejection after liver transplant in HCC patients treated with checkpoint inhibitors

MedXY Editorial TeamNov 6, 2025
graft rejectionhepatocellular carcinomaimmune checkpoint inhibitorsliver transplantation

Highlights

Patients with immune-related adverse events (irAEs) during pretransplant immune checkpoint inhibitor (ICI) therapy had a markedly higher odds of post‑transplant liver allograft rejection (OR 9.17).

A short washout period from last ICI dose to transplantation (<30 days) and recipient age under 40 years were additional independent risk factors; a multivariable model showed acceptable discrimination (AUC 0.788).

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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