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Out-of-Hours Liver Transplantation: Identifying High-Risk Timeframes and Implications for Patient Outcomes
Gastroenterologyliver transplantationOut-of-Hours Surgery

Out-of-Hours Liver Transplantation: Identifying High-Risk Timeframes and Implications for Patient Outcomes

By MedXY|Sep 19, 2026

A Swedish national retrospective study reveals that liver transplantations initiated between 17:00 and 05:59 are linked to significantly increased postoperative complications and healthcare costs, highlighting the need for optimized schedul

Integrative Muscle-Adipose Score (IMAS): Enhancing Sex-Sensitive Prognostication After Liver Transplantation
Gastroenterologyliver transplantation
body composition

Integrative Muscle-Adipose Score (IMAS): Enhancing Sex-Sensitive Prognostication After Liver Transplantation

By MedXY|Sep 18, 2026

The Integrative Muscle-Adipose Score (IMAS) combines muscle and fat measures into a sex-specific tool that accurately predicts long-term survival and postoperative complications in liver transplant recipients, outperforming existing models.

Comparative Real-World Outcomes of Hypothermic Oxygenated and Normothermic Machine Perfusion in Liver Transplantation
Gastroenterologyhypothermic oxygenated perfusionnormothermic machine perfusion

Comparative Real-World Outcomes of Hypothermic Oxygenated and Normothermic Machine Perfusion in Liver Transplantation

By MedXY|Sep 12, 2026

This international cohort study evaluates hypothermic oxygenated perfusion (HOPE) versus normothermic machine perfusion (NMP) in liver transplantation, revealing comparable high graft survival despite differing donor risk profiles and highl

Metabolite-Mediated Neurocognitive Revival Following Liver Transplantation: Insights into Cortical Network Reactivation
GastroenterologyNeuroinflammationNeurocognitive Recovery

Metabolite-Mediated Neurocognitive Revival Following Liver Transplantation: Insights into Cortical Network Reactivation

By MedXY|Sep 3, 2026

Liver transplantation facilitates early neurocognitive recovery in end-stage liver disease patients by restoring cortical network activities, with S-methyl-5′-thioadenosine playing a pivotal neuroprotective role through modulating neu

Elevated Preoperative Serum Renin Predicts Vasopressor Need and Acute Kidney Injury in Liver Transplant Patients
Critical Careliver transplantationvasopressor requirements

Elevated Preoperative Serum Renin Predicts Vasopressor Need and Acute Kidney Injury in Liver Transplant Patients

By MedXY|Aug 18, 2026

Pre-liver transplantation elevated serum renin levels correlate with increased intraoperative vasopressor use and postoperative acute kidney injury, suggesting its potential as a predictive biomarker for perioperative management and renal r

Long-Term Survival and Curative Potential of Liver Transplantation for Nonresectable Colorectal Liver Metastases: Insights from the SECA-II Study
General SurgeryCurative treatmentliver transplantation

Long-Term Survival and Curative Potential of Liver Transplantation for Nonresectable Colorectal Liver Metastases: Insights from the SECA-II Study

By MedXY|Aug 14, 2026

A decade-long follow-up of the SECA-II study demonstrates that liver transplantation in highly selected patients with nonresectable colorectal liver-only metastases yields substantial long-term survival and may offer curative potential even

Outcomes of Colorectal Dysplasia and Cancer in Patients with PSC-IBD Undergoing Liver Transplantation and Colectomy: Insights from a Multicenter Study
Gastroenterologycolorectal cancerinflammatory bowel disease

Outcomes of Colorectal Dysplasia and Cancer in Patients with PSC-IBD Undergoing Liver Transplantation and Colectomy: Insights from a Multicenter Study

By MedXY|Jul 15, 2026

This multicenter retrospective study examines colorectal dysplasia and malignancy outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease undergoing liver transplantation and colectomy, revealing comparable 5

Impact of Modified Frailty Index on Liver Transplant Outcomes: Insights from a Multicenter Cohort Study
Gastroenterologyliver transplantationModified Frailty Index

Impact of Modified Frailty Index on Liver Transplant Outcomes: Insights from a Multicenter Cohort Study

By MedXY|Jul 8, 2026

This study demonstrates that the 5-variable Modified Frailty Index effectively predicts short- and long-term morbidity and mortality after liver transplantation, supporting its use in pretransplant assessment and perioperative planning.

RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice
Gastroenterologyhepatocellular carcinomaliver transplantation

RETREAT Score Stratifies Long-Term Hepatocellular Carcinoma Recurrence Risk After Liver Transplantation in Real-World Practice

By MedXY|Jun 7, 2026

A single-center validation study shows the RETREAT score reliably predicts long-term HCC recurrence after liver transplantation and identifies patients with markedly different recurrence-free and overall survival trajectories.

Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes
Gastroenterologycandidate evaluationguideline update

Adult Liver Transplant Candidate Evaluation: What the New AASLD/AST Guideline Changes

By MedXY|Jun 6, 2026

The updated AASLD/AST guideline clarifies how adults should be evaluated for liver transplantation, emphasizing equitable access, multidisciplinary assessment, psychosocial readiness, and structured risk–benefit decision-making.

Y90 Radioembolization as a Bridge to Liver Transplantation in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
Gastroenterologydownstaginghepatocellular carcinoma

Y90 Radioembolization as a Bridge to Liver Transplantation in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

By MedXY|Jun 3, 2026

Y90 radioembolization downstaged about one-quarter of HCC patients with portal vein tumor thrombosis to transplant eligibility, and those who received liver transplantation had markedly better cancer-related outcomes and survival.

Beyond Traditional Risk Factors: Deconstructing the Burden of Coronary Atherosclerosis in Liver Transplant Recipients
Clinical Updatescardiovascular riskcoronary artery disease

Beyond Traditional Risk Factors: Deconstructing the Burden of Coronary Atherosclerosis in Liver Transplant Recipients

By MedXY|Mar 7, 2026

A landmark nationwide study reveals that liver transplant recipients face significantly higher prevalence and severity of coronary atherosclerosis and high-risk plaque compared to matched controls, independent of traditional cardiovascular

Beyond MELD: The Liver Immune Frailty Index (LIFI) Predicts Post-Transplant Mortality with High Precision
Gastroenterologybiomarkersliver transplantation

Beyond MELD: The Liver Immune Frailty Index (LIFI) Predicts Post-Transplant Mortality with High Precision

By MedXY|Feb 21, 2026

Researchers have developed the Liver Immune Frailty Index (LIFI), a biomarker-based tool using fractalkine and MMP3 to predict post-liver transplant mortality. With a C-statistic of 0.83, LIFI identifies high-risk candidates, potentially tr

Immune-related adverse events strongly predict early graft rejection after liver transplant in HCC patients treated with checkpoint inhibitors
Gastroenterologygraft rejectionhepatocellular carcinoma

Immune-related adverse events strongly predict early graft rejection after liver transplant in HCC patients treated with checkpoint inhibitors

By MedXY|Nov 6, 2025

A multicentre retrospective cohort found that pretransplant immune-related adverse events (irAEs) markedly increase the risk of early liver allograft rejection after liver transplantation for hepatocellular carcinoma (HCC). IrAEs, short ICI

Predicting Early Acute Kidney Injury After Liver Transplantation: A Clinically Useful 48‑Hour Risk Model
Gastroenterologyliver transplantationperioperative risk

Predicting Early Acute Kidney Injury After Liver Transplantation: A Clinically Useful 48‑Hour Risk Model

By MedXY|Nov 5, 2025

A single-center study developed and internally validated a 48‑hour post‑liver transplant AKI risk model using five readily available preoperative and intraoperative variables (HE, alcohol cirrhosis, ALBI ≥ −1.78, operation time ≥560 min, an

Expanding Donor Pools: Outcomes of Liver Transplantation Using Grafts from Medical Assistance in Dying Donors in Canada
Gastroenterologydonation after circulatory deathgraft survival

Expanding Donor Pools: Outcomes of Liver Transplantation Using Grafts from Medical Assistance in Dying Donors in Canada

By MedXY|Oct 31, 2025

This Canadian multicenter study evaluates liver transplant outcomes using grafts from donation after medical assistance in dying donors, showing comparable survival and complication rates to standard donors and increasing transplant activit

Breaking New Ground: The First Genetically Engineered Pig-to-Human Liver Xenotransplantation
Gastroenterologyliver transplantationthrombotic microangiopathy

Breaking New Ground: The First Genetically Engineered Pig-to-Human Liver Xenotransplantation

By MedXY|Oct 27, 2025

This landmark study reports the first successful genetically engineered pig auxiliary liver transplanted into a living human, revealing critical insights on immunological compatibility and post-transplant complications, advancing liver xeno

Optimizing Treatment Selection for Hepatocellular Carcinoma: Machine Learning Guidance in Choosing Liver Transplantation versus Surgical Resection
General Surgeryhepatocellular carcinomaliver transplantation

Optimizing Treatment Selection for Hepatocellular Carcinoma: Machine Learning Guidance in Choosing Liver Transplantation versus Surgical Resection

By MedXY|Oct 9, 2025

A machine learning model accurately stratifies patients with hepatocellular carcinoma to guide individualized selection between liver transplantation and surgical resection, improving survival outcomes while addressing donor scarcity and pa

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