Cryoballoon Ablation Is Non‑Inferior to Radiofrequency for 1‑Year Arrhythmia Control in Persistent AF — but Left Atrium Shrinks Less: Insights from the CRRF‑PeAF Trial
Highlights
– In the multicentre randomized CRRF‑PeAF trial (n=499), cryoballoon pulmonary vein isolation (PVI) was non‑inferior to radiofrequency (RF) ablation for the composite endpoint of recurrent atrial tachyarrhythmia at 1 year (after a 90‑day blanking period): 22.5% vs 23.2% respectively (HR 0.99; 95% CI 0.69–1.43; P = .96).
– At 1 year, RF ablation produced a greater median reduction in left atrial volume index than cryoballoon ablation: −11 mL/m2 (IQR −19 to −4) vs −4 mL/m2 (IQR −13 to 3), P < .001, suggesting more pronounced reverse atrial remodelling after RF‑based strategies in this cohort.
Sign in free to continue reading
Create or use your MedXY account to unlock the complete article.
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.