Targeting Capillary Refill Time in Early Septic Shock Reduced Duration of Organ Support: Key Findings from ANDROMEDA‑SHOCK‑2

Highlights

– In a multinational randomized trial (ANDROMEDA‑SHOCK‑2), personalized hemodynamic resuscitation targeting capillary refill time (CRT) improved a hierarchical composite of death, duration of organ support, and length of stay (win ratio 1.16, 95% CI 1.02–1.33; P = .04).

– The primary benefit was a shorter duration of vital support (vasoactives, mechanical ventilation, kidney replacement therapy); mortality differences were small and not the main driver.