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This review elucidates the contrasting roles of ACADM-mediated fatty acid β-oxidation in atherosclerosis and abdominal aortic aneurysm, highlighting differential lipid metabolism and translational implications for diagnosis and therapy.
This review synthesizes evidence on colchicine’s efficacy in secondary stroke prevention, emphasizing the impact of concomitant atherosclerosis on outcomes from the CONVINCE trial and meta-analyses.
GLP-1 receptor agonists significantly reduce atherosclerosis progression, inflammatory biomarkers, and cardiovascular events independent of glycaemic control and obesity status, evidenced by robust preclinical and large-scale clinical data.
This study compares the predictive value of non-HDL cholesterol and apolipoprotein B for atherosclerotic cardiovascular disease risk in individuals not on lipid-lowering medication.
In 2 prospective cohorts, blood DNA methylation was associated with carotid, coronary, and peripheral atherosclerosis, but most signals overlapped with smoking and cardiometabolic risk factors rather than vessel-specific biology.
In patients with acute myocardial infarction, silent plaque rupture was found in 12% of non-obstructive lesions in non-infarct-related arteries. Larger plaques, positive remodeling, and thinner fibrous caps were linked to rupture, and more
The Essence-TIMI 73b trial reveals that despite a 64% reduction in triglycerides and a 72% drop in remnant cholesterol via olezarsen, non-calcified coronary plaque volume remained unchanged over 12 months.
Research reveals that PlexinD1 mediates macrophage-driven inflammation in response to disturbed blood flow. By targeting this pathway, scientists have successfully attenuated plaque progression in preclinical models, paving the way for adva
Recent research identifies a specific molecular pathway—driven by HSF1 activation and increased cholesterol biosynthesis in smooth muscle cells—that explains why certain ACTA2 mutations predispose patients to premature atherosclerotic cardi
This Mendelian randomization study reveals that coronary plaque burden significantly mediates the link between traditional risk factors and adverse events like myocardial infarction and heart failure, reinforcing the necessity of early prim
A large-scale comparative study of 3,508 patients reveals that atrial fibrillation and atherosclerosis produce significantly different vascular brain lesions on MRI, with AF favoring non-lacunar infarcts and periventricular white matter cha
A large-scale cohort study from the Western Denmark Heart Registry demonstrates that high LDL-C remains a significant predictor of non-calcified plaque and coronary heart disease events in patients with a CAC score of zero, particularly amo
A pilot study evaluating hair silicon as a long-term mineral marker found no significant association between silicon concentrations and coronary artery disease (CAD) severity or inflammatory markers, suggesting silicon may be metabolically
A Swedish cohort study of 10,222 men linked adolescent blood pressure to coronary atherosclerosis by CCTA ~40 years later; higher systolic BP in adolescence, even in the ‘elevated’ range, was associated with greater odds of severe (>50%)
New animal research links oral microplastic exposure to dramatic increases in arterial plaque—especially in males—by injuring endothelial cells and provoking inflammation and oxidative stress.
Preclinical AHA 2025 data show MRT-8102, an oral NEK7-directed molecular glue degrader, selectively degrades NEK7, suppresses NLRP3 inflammasome activation and pyroptosis across species, and reduces multi-cytokine release—supporting Phase 1
In MESA, baseline subclinical arteriosclerosis and atherosclerosis scores predicted greater cognitive decline and higher odds of MCI/dementia over 20 years, independently of clinical dementia risk factors.
This study highlights the association between illicit anabolic steroid use and adverse cardiovascular outcomes in both sexes, emphasizing the need for preventive strategies in recreational sports.
New research identifies transcription factor ATF3 as a key regulator of vascular smooth muscle cell aging and reveals low-dose trazosin, a commonly used antihypertensive, as a potential therapy to delay vascular aging and atherosclerosis pr
Beyond cholesterol and blood pressure, homocysteine silently hardens arteries, driving cardiovascular disease progression independently—latest research reveals its biomechanical impact and prevention strategies.
