Effectiveness of Automated Closed-Loop Ventilation versus Protocolized Conventional Ventilation in Critically Ill Adults: A Comprehensive Evidence Review

MedXY Editorial Team•Dec 12, 2025•Clinical Updates

Automated closed-loop ventilation systems such as INTELLiVENT-ASV continuously adjust ventilator settings based on patient physiology, aiming for optimized lung-protective ventilation.
In a landmark international randomized controlled trial, early use of automated closed-loop ventilation did not significantly increase ventilator-free days at day 28 compared to protocolized conventional ventilation in critically ill adults.
Automated ventilation demonstrated improved ventilation quality and a more favorable safety profile, with reduced incidences of severe hypercapnia and hypoxemia and less frequent requirement of rescue therapies.
Secondary benefits include reduction in manual ventilator adjustments and improved nurse and physician acceptance, highlighting potential workflow and workload advantages.

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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Automated closed-loop ventilation systems such as INTELLiVENT-ASV continuously adjust ventilator settings based on patient physiology, aiming for optimized lung-protective ventilation.
In a landmark international randomized controlled trial, early use of automated closed-loop ventilation did not significantly increase ventilator-free days at day 28 compared to protocolized conventional ventilation in critically ill adults.
Automated ventilation demonstrated improved ventilation quality and a more favorable safety profile, with reduced incidences of severe hypercapnia and hypoxemia and less frequent requirement of rescue therapies.
Secondary benefits include reduction in manual ventilator adjustments and improved nurse and physician acceptance, highlighting potential workflow and workload advantages.