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A deep learning model identifying ARDS features on chest X-rays independently predicts 28-day mortality and ventilator duration beyond traditional clinical measures in patients undergoing invasive mechanical ventilation.
Continuous automatic cuff pressure monitoring significantly lowers ventilator-associated pneumonia incidence in critically ill children by ensuring better pressure control, offering an effective preventive strategy in pediatric intensive ca
This RCT demonstrates that combining multidimensional functional training with inspiratory muscle training and chest physiotherapy improves weaning success, muscle strength, functional independence, pain reduction, and ICU stay following em
This review critically examines the SAVE-ICU trial assessing isoflurane inhaled sedation versus intravenous sedation in mechanically ventilated adults with acute hypoxemic respiratory failure, highlighting implications for clinical practice
This study identifies three distinct phenotypes among patients failing to wean from invasive mechanical ventilation, linking failed initial attempts, withdrawal decisions, and mortality, highlighting the need for tailored management strateg
A randomized controlled trial demonstrates that adjunct low-dose ketamine infusion safely decreases opioid use in mechanically ventilated adults without increasing delirium or adverse events, suggesting potential benefits in ICU analgosedat
Mechanical ventilation during surgery induces neutrophil extracellular vesicles that propagate lung inflammation and contribute to postoperative pulmonary complications, highlighting potential new biomarkers and therapeutic targets.
This study evaluates ECMO as a standalone respiratory support in ARDS patients avoiding invasive mechanical ventilation, highlighting outcomes, strategy failures, and mortality implications.
The EVER trial examined if a structured early mobilization protocol improves functional outcomes in ventilated patients with sepsis or respiratory failure. Despite earlier and increased mobilization, no significant functional benefit was ob
This study reveals that acute hypoxemic respiratory failure (AHRF) affects half of ICU patients needing respiratory support, with severity linked to worse outcomes. Lung-protective ventilation is common, underscoring the need for standardiz
This study reveals how respiratory system elastance influences the effects of tidal volume and respiratory rate on outcomes in mechanically ventilated acute brain injury patients, suggesting personalized ventilation strategies based on resp
RCT evidence shows that restrictive low-use versus liberal high-use physical restraint strategies in mechanically ventilated ICU patients do not differ in days alive without delirium or coma at 14 days.
A novel artificial intelligence algorithm enables continuous, noninvasive monitoring of inspiratory muscle effort and patient-ventilator dyssynchrony during mechanical ventilation, demonstrating accuracy comparable to invasive gold standard
In 37 North American hospitals, proning of eligible mechanically ventilated patients increased markedly during COVID-19, then fell post-pandemic, with substantial interhospital variation throughout.
A large analysis suggests the predicted body weight equation overestimates lung size in critically ill women, increasing the risk of higher driving pressures and contributing to excess mortality under standard tidal-volume targeting.
Bayesian re-analysis of the RELAx trial suggests a 75-78% probability that a lower PEEP strategy is superior to higher PEEP in ICU patients without ARDS, with even higher benefits observed in specific clinical subgroups.
A landmark 20-year analysis of over 200,000 mechanically ventilated ARDS patients reveals a striking paradox—mortality declined during the ICD-9 era but increased after ICD-10 adoption, challenging assumptions about ARDS outcomes and highli
The DEMEL trial found that while 0.3 mg of melatonin achieved a superior pharmacokinetic profile over 3 mg, it failed to reduce delirium incidence or improve clinical outcomes in mechanically ventilated patients compared to placebo.
The DESIGNATION trial demonstrates that driving pressure-guided high PEEP with recruitment maneuvers does not reduce postoperative pulmonary complications compared to standard low PEEP in patients undergoing open abdominal surgery, while si
This article evaluates the IMPROVE-2 trial and a recent meta-analysis on driving pressure-guided PEEP. Despite physiological improvements in lung compliance, individualized PEEP failed to reduce postoperative respiratory failure in emergenc
